Detailed information NTG0713639

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: NPS16_RS02660
• Genome accession: NZ_CP101986
• Coordinates: 546085..548346 (-)
• Length: 753 a.a.
• NCBI ID: WP_002266431.1
• Uniprot ID: A0AAX1JZI0
• Organism: Streptococcus mutans strain COCC33-14
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 541085..553346

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NPS16_RS02645 (NPS16_02645)	ileS	541583..544375 (+)	2793	WP_102990533.1	isoleucine--tRNA ligase	-
NPS16_RS02650 (NPS16_02650)	-	545150..545452 (-)	303	WP_002263571.1	DUF1827 family protein	-
NPS16_RS02655 (NPS16_02655)	-	545519..545974 (-)	456	WP_002263570.1	NUDIX hydrolase	-
NPS16_RS02660 (NPS16_02660)	clpE	546085..548346 (-)	2262	WP_002266431.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
NPS16_RS02665 (NPS16_02665)	argF	548603..549583 (+)	981	WP_002266430.1	ornithine carbamoyltransferase	-
NPS16_RS02670 (NPS16_02670)	-	549660..549890 (+)	231	WP_002263567.1	YkuJ family protein	-
NPS16_RS02675 (NPS16_02675)	-	550104..550790 (+)	687	WP_002263566.1	amino acid ABC transporter permease	-
NPS16_RS02680 (NPS16_02680)	-	550790..551524 (+)	735	WP_002263565.1	amino acid ABC transporter ATP-binding protein	-
NPS16_RS02685 (NPS16_02685)	-	551717..552193 (+)	477	WP_019316253.1	ferrous iron transport protein A	-

Sequence

Protein

• Length: 753 a.a.
• Molecular weight: 83747.88 Da
• Isoelectric Point: 5.0580

>NTDB_id=713639 NPS16_RS02660 WP_002266431.1 546085..548346(-) (clpE) [Streptococcus mutans strain COCC33-14]
MLCQNCKLNEATIHLYANVNGQQKQIDLCQNCYQIMKTDPENGPLNHLSQQNSSSINPFFDDFFGDLNNFRAFNNQDLPN
TPPTQAGGGNGNGGNNRRPGGPQQQASQKPNGLLEEFGINLTDIARKGEIDPVIGRDEEITRVIEILNRRTKNNPVLIGE
PGVGKTAVVEGLAQKIVDGDVPQKLHGKNVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGS
AGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVAETITILKGIQPKYEDYHHVKYTDE
AIEAAANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDHRLIEAENLKAQATRDEDYEKAAYFRDQIAKYKE
MQSAKLDKENTPVITEKNIEVIVEQKTNIPVGELKEKEQSQLIHLADDLKTRVIGQDAAVDKIAKAIRRNRVGLGTPNRP
IGSFLFVGPTGVGKTELSKQLAIELFGSEDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLD
EVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEANVGFGASREGRTNSVLGELGNFFSPEFMNR
FDGIIEFQALSKDNLLQIVSLMLDDVNQRLAVNAIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLEH
PDQKELKAIMTSNGKIVIRASNKVETVTKATSD

Nucleotide

• Length: 2262 bp

>NTDB_id=713639 NPS16_RS02660 WP_002266431.1 546085..548346(-) (clpE) [Streptococcus mutans strain COCC33-14]
ATGCTCTGTCAAAATTGTAAATTAAATGAAGCGACTATTCATCTATATGCTAATGTTAATGGTCAGCAAAAGCAGATTGA
TCTTTGTCAAAATTGTTATCAAATTATGAAAACAGATCCTGAAAATGGACCTTTAAATCATCTTTCGCAACAAAATTCAT
CATCCATCAATCCTTTCTTTGATGATTTCTTTGGCGATTTGAATAATTTTCGTGCCTTTAATAATCAAGATCTGCCAAAC
ACACCGCCAACACAAGCTGGCGGCGGCAATGGCAACGGAGGCAATAATCGCCGTCCCGGCGGACCTCAGCAACAGGCCTC
CCAAAAGCCAAATGGGTTGCTTGAAGAGTTTGGTATTAATTTAACAGATATTGCGCGCAAGGGTGAAATTGATCCTGTTA
TTGGCCGTGATGAAGAAATCACAAGGGTTATCGAAATTCTCAACCGTCGCACAAAGAATAATCCTGTTCTTATTGGAGAA
CCGGGTGTCGGTAAAACTGCTGTTGTCGAAGGACTGGCGCAAAAAATTGTTGATGGTGATGTTCCACAAAAATTACATGG
AAAAAATGTCATTCGTCTGGACGTCGTCAGCCTTGTTCAAGGTACTGGTATTCGAGGCCAATTTGAAGAACGGATGCAAA
AATTAATGGAAGAAATCCGTCAACGTCAAGATGTTATTCTTTTCATTGATGAAATTCATGAAATTGTTGGTGCTGGTTCT
GCTGGCGATGGCAATATGGATGCCGGAAATATTTTAAAACCCGCTTTGGCACGCGGTGAGCTTCAACTTGTTGGTGCTAC
AACACTCAATGAATATCGGATTATTGAAAAAGATGCCGCTTTGGAACGTCGAATGCAACCCGTAAAAGTTGATGAACCTA
GTGTTGCAGAAACCATAACGATTCTTAAAGGTATTCAGCCCAAATATGAAGATTACCATCATGTAAAGTATACAGATGAA
GCGATTGAAGCTGCTGCAAATCTTTCAAATCGTTACATTCAGGATCGTTTTTTACCTGATAAGGCTATTGATCTTCTAGA
TGAAGCTGGCTCTAAAATGAATTTAACACTTAACTTTGTAGATCCTAAAGAAATTGATCACCGCTTGATTGAAGCCGAGA
ATCTAAAAGCTCAAGCAACCCGTGATGAAGATTATGAAAAAGCAGCTTACTTCCGTGATCAAATTGCCAAATACAAGGAA
ATGCAATCCGCTAAACTTGATAAGGAGAATACTCCTGTTATTACAGAAAAAAATATTGAAGTAATTGTCGAGCAAAAGAC
CAATATTCCTGTTGGTGAATTAAAAGAAAAGGAACAATCACAATTAATTCATCTCGCTGACGATCTTAAAACGCGTGTTA
TTGGACAGGATGCTGCTGTTGATAAAATTGCTAAAGCTATTCGCCGCAATCGTGTTGGACTAGGCACTCCAAATCGGCCA
ATTGGTTCTTTCCTTTTTGTCGGCCCTACTGGTGTTGGTAAAACGGAACTCTCTAAACAATTAGCCATTGAGCTTTTTGG
TTCTGAAGATAGTATGATTCGTTTCGATATGAGTGAATACATGGAAAAACATGCTGTGGCTAAACTTGTTGGTGCACCTC
CGGGATATGTCGGTTATGAAGAAGCTGGTCAGTTAACCGAAAAAGTTCGTCGCAACCCTTATTCATTGATCTTACTCGAT
GAAGTTGAAAAAGCTCACCCAGATGTCATGCATATGTTCTTACAAGTGCTTGATGATGGTCGTCTAACGGATGGGCAAGG
ACGCACTGTCAGCTTTAAGGATACTATTATTATCATGACCTCAAATGCTGGTACAGGGAAATCTGAAGCTAATGTTGGTT
TTGGTGCCAGTCGAGAAGGCCGTACTAATTCTGTTCTAGGCGAATTGGGTAACTTCTTTAGCCCTGAATTTATGAACCGT
TTTGATGGTATCATCGAATTTCAGGCTTTAAGCAAGGATAATCTTCTTCAAATTGTTTCTCTCATGCTGGATGACGTTAA
TCAACGTTTAGCTGTTAATGCTATTCACCTTGATGTAACTGATAAAGTTAAAGAAAAATTGGTTGATCTTGGTTATGATC
CTAAAATGGGAGCAAGACCGCTGCGTCGTACTATCCAAGAACATATTGAAGATGCTATTACGGATTTCTACTTAGAGCAT
CCTGATCAAAAAGAACTAAAAGCTATTATGACAAGCAACGGCAAAATTGTTATCAGGGCTTCTAACAAAGTCGAGACGGT
TACCAAAGCAACTTCAGATTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (479-642)

• AAA lid domain (AAA_lid_9) (294-391)

• ATPase family associated with various cellular activities (AAA) (AAA) (156-275)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (650-721)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	99.734	100	0.997
clpE	Streptococcus pneumoniae Rx1	82.62	99.336	0.821
clpE	Streptococcus pneumoniae D39	82.62	99.336	0.821
clpE	Streptococcus pneumoniae R6	82.62	99.336	0.821
clpE	Streptococcus pneumoniae TIGR4	82.62	99.336	0.821
clpC	Lactococcus lactis subsp. cremoris KW2	76.291	100	0.765
clpC	Bacillus subtilis subsp. subtilis str. 168	53.159	86.189	0.458
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48	86.321	0.414
clpC	Streptococcus pneumoniae Rx1	49.355	82.337	0.406
clpC	Streptococcus pneumoniae D39	49.355	82.337	0.406
clpC	Streptococcus pneumoniae TIGR4	49.194	82.337	0.405
clpC	Streptococcus thermophilus LMD-9	47.764	83.134	0.397
clpC	Streptococcus thermophilus LMG 18311	47.444	83.134	0.394
clpC	Streptococcus mutans UA159	47.011	82.205	0.386