Detailed information NTG0713510

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: NPS18_RS07035
• Genome accession: NZ_CP101984
• Coordinates: 1451551..1452432 (-)
• Length: 293 a.a.
• NCBI ID: WP_002262935.1
• Uniprot ID: Q8DT59
• Organism: Streptococcus mutans strain UA-159
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1446551..1457432

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NPS18_RS07010 (NPS18_07010)	vicR	1447445..1448152 (-)	708	WP_002262930.1	response regulator YycF	Regulator
NPS18_RS07015 (NPS18_07015)	-	1448505..1449287 (+)	783	WP_002262931.1	amino acid ABC transporter ATP-binding protein	-
NPS18_RS07020 (NPS18_07020)	-	1449284..1450096 (+)	813	WP_002262932.1	transporter substrate-binding domain-containing protein	-
NPS18_RS07025 (NPS18_07025)	-	1450114..1450818 (+)	705	WP_002262933.1	amino acid ABC transporter permease	-
NPS18_RS07030 (NPS18_07030)	-	1450833..1451483 (+)	651	WP_002262934.1	amino acid ABC transporter permease	-
NPS18_RS07035 (NPS18_07035)	endA	1451551..1452432 (-)	882	WP_002262935.1	DNA/RNA non-specific endonuclease	Machinery gene
NPS18_RS07040 (NPS18_07040)	-	1452474..1452662 (-)	189	WP_002262936.1	DNA-directed RNA polymerase subunit beta	-
NPS18_RS07045 (NPS18_07045)	murA	1452665..1453936 (-)	1272	WP_002262937.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
NPS18_RS07050 (NPS18_07050)	-	1454002..1454235 (-)	234	WP_002285829.1	DUF1146 family protein	-
NPS18_RS07055 (NPS18_07055)	-	1454508..1454924 (-)	417	WP_002262939.1	F0F1 ATP synthase subunit epsilon	-
NPS18_RS07060 (NPS18_07060)	atpD	1454938..1456344 (-)	1407	WP_002262940.1	F0F1 ATP synthase subunit beta	-
NPS18_RS07065 (NPS18_07065)	-	1456370..1457248 (-)	879	WP_002262941.1	F0F1 ATP synthase subunit gamma	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 32130.72 Da
• Isoelectric Point: 9.5337

>NTDB_id=713510 NPS18_RS07035 WP_002262935.1 1451551..1452432(-) (endA) [Streptococcus mutans strain UA-159]
MTRKTNKSQRKQQKLCLSLLAALSVFVCTYIATSDHIADSNPIKQAAQLLTGKNKDILSNGSMSHQATPSQELANTVMTD
AVKNALGRQIEWSGAGSFIINHNKTDLNADVASQPYASNQTKIVQGQTVPTVANALLSKATRQYRNRQETGNGRTNWQPA
GWHQLYDLPGDYDHAVDRGHLLAYALVGGLKRFDASTSNPQNVATQAAWANEANSSNSRGQNYYETLIRKALDSHKRVRY
RVTLIYDDNNDILASGSHLEAKSSDGSLEFNVFIPNVQSGLTFDYATGQVKAN

Nucleotide

• Length: 882 bp

>NTDB_id=713510 NPS18_RS07035 WP_002262935.1 1451551..1452432(-) (endA) [Streptococcus mutans strain UA-159]
ATGACTAGAAAAACGAACAAGTCTCAGCGAAAACAGCAAAAATTATGCTTATCTCTCCTTGCTGCTTTGAGCGTATTTGT
TTGTACTTATATTGCAACCAGTGATCATATTGCTGATAGTAACCCTATAAAGCAGGCTGCCCAATTATTGACAGGTAAAA
ACAAGGATATACTTTCAAATGGTTCAATGAGCCATCAAGCGACTCCCAGTCAAGAATTAGCCAATACTGTTATGACGGAT
GCAGTAAAAAATGCCTTGGGTAGACAAATTGAATGGAGTGGTGCAGGTTCTTTCATTATTAATCATAATAAAACTGACCT
TAACGCTGATGTTGCTAGCCAACCGTATGCTAGTAATCAGACCAAAATCGTTCAAGGACAGACAGTACCAACAGTAGCAA
ATGCTTTGTTAAGTAAGGCTACTCGTCAGTACCGAAACCGCCAAGAGACAGGAAATGGCAGGACAAATTGGCAGCCAGCA
GGCTGGCATCAGCTTTATGATTTGCCGGGTGACTATGATCACGCGGTTGATCGTGGACACTTATTGGCTTATGCTTTGGT
TGGTGGTTTGAAACGATTTGATGCTTCAACGAGTAATCCTCAAAATGTAGCAACACAAGCAGCTTGGGCTAATGAAGCCA
ATAGTTCAAACTCAAGGGGACAAAATTATTATGAAACACTGATTAGAAAAGCTTTGGATAGTCATAAGCGTGTTCGTTAT
CGTGTGACTCTTATCTATGATGACAACAATGATATCTTAGCCAGTGGCAGTCATCTAGAAGCCAAATCATCAGATGGCAG
TCTAGAGTTCAATGTCTTTATTCCTAATGTTCAAAGCGGTTTGACCTTTGATTATGCAACAGGACAAGTTAAGGCAAATT
AA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (99-251)

3D structure

• AlphaFold DB: Q8DT59

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	64.103	79.863	0.512
endA	Streptococcus pneumoniae D39	64.103	79.863	0.512
endA	Streptococcus pneumoniae R6	64.103	79.863	0.512
endA	Streptococcus pneumoniae TIGR4	64.103	79.863	0.512