Detailed information NTG0708886

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NMK49_RS09215
• Genome accession: NZ_CP101124
• Coordinates: 1892566..1893609 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus RN4220
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1887566..1898609

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NMK49_RS09185	-	1887984..1889240 (-)	1257	WP_001795438.1	aminopeptidase	-
NMK49_RS09190	-	1889243..1889443 (-)	201	WP_000180461.1	DUF1128 family protein	-
NMK49_RS09195	-	1889590..1890054 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NMK49_RS09200	-	1890061..1890336 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NMK49_RS09205	-	1890614..1891831 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
NMK49_RS09210	vraR	1891947..1892576 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NMK49_RS09215	vraS	1892566..1893609 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NMK49_RS09220	liaF	1893606..1894307 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NMK49_RS09225	-	1894322..1894708 (-)	387	WP_001110179.1	hypothetical protein	-
NMK49_RS09230	map	1894925..1895683 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NMK49_RS09235	-	1896211..1897197 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
NMK49_RS09240	-	1897628..1898041 (-)	414	WP_001549145.1	hypothetical protein	-
NMK49_RS09245	-	1898070..1898180 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=708886 NMK49_RS09215 WP_001017131.1 1892566..1893609(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=708886 NMK49_RS09215 WP_001017131.1 1892566..1893609(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1