Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   K6J63_RS04385 Genome accession   NZ_AP018765
Coordinates   833591..834811 (+) Length   406 a.a.
NCBI ID   WP_011271971.1    Uniprot ID   Q4QNP6
Organism   Haemophilus influenzae strain CHBN-II-2 isolate 12H49     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 828591..839811
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6J63_RS04365 (CHBNII2_08430) corC 829558..830457 (-) 900 WP_005656283.1 CNNM family magnesium/cobalt transport protein CorC -
  K6J63_RS04370 (CHBNII2_08440) ampD 831079..831639 (-) 561 WP_011271974.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  K6J63_RS04375 (CHBNII2_08450) pilA 831754..832203 (+) 450 WP_011271973.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  K6J63_RS04380 (CHBNII2_08460) pilB 832200..833594 (+) 1395 WP_011271972.1 GspE/PulE family protein Machinery gene
  K6J63_RS04385 (CHBNII2_08470) pilC 833591..834811 (+) 1221 WP_011271971.1 type II secretion system F family protein Machinery gene
  K6J63_RS04390 (CHBNII2_08480) pilD 834808..835500 (+) 693 WP_105886719.1 A24 family peptidase Machinery gene
  K6J63_RS04395 (CHBNII2_08490) rho 835554..836816 (-) 1263 WP_015701557.1 transcription termination factor Rho -
  K6J63_RS04400 (CHBNII2_08500) metJ 837064..837381 (+) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  K6J63_RS04405 (CHBNII2_08510) - 837395..837781 (-) 387 WP_105886720.1 Cu(I)-responsive transcriptional regulator -
  K6J63_RS04410 (CHBNII2_08520) - 837858..838064 (+) 207 WP_005631184.1 heavy-metal-associated domain-containing protein -
  K6J63_RS04415 (CHBNII2_08530) - 838150..838356 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -
  K6J63_RS04420 (CHBNII2_08540) - 838442..838648 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -
  K6J63_RS04425 (CHBNII2_08550) - 838734..838940 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46259.57 Da        Isoelectric Point: 10.0444

>NTDB_id=70766 K6J63_RS04385 WP_011271971.1 833591..834811(+) (pilC) [Haemophilus influenzae strain CHBN-II-2 isolate 12H49]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISRGLTHIKLQQNWQFGAKPKNSEISELLNQLATLLQSVIPLKNSL
QILQQNCTQIMLNKWLERLLQSIESGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIAPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIADNYQEKLNHQIDLLSQMLEPLMMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=70766 K6J63_RS04385 WP_011271971.1 833591..834811(+) (pilC) [Haemophilus influenzae strain CHBN-II-2 isolate 12H49]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCGCACTTTCAGTTAATAAGCCGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGGCAAAAC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCGACATTGCTACAGTCCGTAATTCCGTTAAAAAACAGCCTA
CAAATTTTGCAACAAAATTGTACTCAAATTATGCTCAACAAATGGCTTGAACGACTGCTTCAATCCATTGAATCTGGCTT
AGCATTCTCACAAGCCATTGAACAACAAGGAAAATATCTCACACAACAAGAAATTCAACTGATTCAAGTGGGAGAAATGA
CAGGAAAACTTGCCGTAGTTTGTAAAAAAATAGCCACGCACCGTAGTCAATCTTTGGCTTTACAACGCAAATTACAGAAA
ATTATGTTATATCCCTCAATGGTATTGGGAATTTCTCTATTATTGACACTCGCATTACTGCTTTTTATCGCGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCTAATTTCCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATCTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAACAAAGCGG
AAAACTCGCTTTGATGCTAGAGCATATCGCAGATAATTACCAAGAAAAACTTAATCATCAAATTGACTTACTCTCACAAA
TGCTAGAACCATTAATGATGGTAATCATCGGCAGTCTGATTGGGATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QNP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

100

100

1
  pilC Haemophilus influenzae Rd KW20

97.783

100

0.978
  pilC Glaesserella parasuis strain SC1401

38.155

98.768

0.377

Multiple sequence alignment