Detailed information NTG0705174

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NLG45_RS13730
• Genome accession: NZ_CP100428
• Coordinates: 2764882..2765925 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RMSA24
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2759882..2770925

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NLG45_RS13700 (NLG45_13700)	-	2760423..2760533 (+)	111	WP_001790257.1	hypothetical protein	-
NLG45_RS13705 (NLG45_13705)	-	2760562..2760975 (+)	414	WP_001549145.1	hypothetical protein	-
NLG45_RS13710 (NLG45_13710)	-	2761406..2762392 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
NLG45_RS13715 (NLG45_13715)	map	2762808..2763566 (+)	759	WP_000636144.1	type I methionyl aminopeptidase	-
NLG45_RS13720 (NLG45_13720)	-	2763783..2764169 (+)	387	WP_001110179.1	hypothetical protein	-
NLG45_RS13725 (NLG45_13725)	liaF	2764184..2764885 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NLG45_RS13730 (NLG45_13730)	vraS	2764882..2765925 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NLG45_RS13735 (NLG45_13735)	vraR	2765915..2766544 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
NLG45_RS13740 (NLG45_13740)	-	2766656..2767873 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
NLG45_RS13745 (NLG45_13745)	-	2768151..2768426 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
NLG45_RS13750 (NLG45_13750)	-	2768433..2768896 (-)	464	Protein_2698	low molecular weight protein-tyrosine-phosphatase	-
NLG45_RS13755 (NLG45_13755)	-	2769043..2769243 (+)	201	WP_000180463.1	DUF1128 family protein	-
NLG45_RS13760 (NLG45_13760)	-	2769246..2770502 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=705174 NLG45_RS13730 WP_001017131.1 2764882..2765925(+) (vraS) [Staphylococcus aureus strain RMSA24]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=705174 NLG45_RS13730 WP_001017131.1 2764882..2765925(+) (vraS) [Staphylococcus aureus strain RMSA24]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1