Detailed information NTG0700798

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NHB12_RS10055
• Genome accession: NZ_CP099576
• Coordinates: 2031969..2033012 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA1369
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2026969..2038012

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NHB12_RS10025 (NHB12_10025)	-	2027387..2028643 (-)	1257	WP_001795438.1	aminopeptidase	-
NHB12_RS10030 (NHB12_10030)	-	2028646..2028846 (-)	201	WP_000180461.1	DUF1128 family protein	-
NHB12_RS10035 (NHB12_10035)	-	2028993..2029457 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NHB12_RS10040 (NHB12_10040)	-	2029464..2029739 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NHB12_RS10045 (NHB12_10045)	-	2030017..2031234 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
NHB12_RS10050 (NHB12_10050)	vraR	2031350..2031979 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
NHB12_RS10055 (NHB12_10055)	vraS	2031969..2033012 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NHB12_RS10060 (NHB12_10060)	liaF	2033009..2033710 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NHB12_RS10065 (NHB12_10065)	-	2033725..2034111 (-)	387	WP_001110179.1	hypothetical protein	-
NHB12_RS10070 (NHB12_10070)	map	2034328..2035086 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NHB12_RS10075 (NHB12_10075)	-	2035614..2036601 (+)	988	Protein_1948	aromatic acid exporter family protein	-
NHB12_RS10080 (NHB12_10080)	-	2037091..2037504 (-)	414	WP_001549145.1	hypothetical protein	-
NHB12_RS10085 (NHB12_10085)	-	2037533..2037643 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=700798 NHB12_RS10055 WP_001017131.1 2031969..2033012(-) (vraS) [Staphylococcus aureus strain MRSA1369]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=700798 NHB12_RS10055 WP_001017131.1 2031969..2033012(-) (vraS) [Staphylococcus aureus strain MRSA1369]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1