Detailed information NTG0694807

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NB630_RS11325
• Genome accession: NZ_CP098255
• Coordinates: 2345427..2346470 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2340427..2351470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NB630_RS11295 (NB630_11295)	-	2340870..2340980 (+)	111	WP_001790257.1	hypothetical protein	-
NB630_RS11300 (NB630_11300)	-	2341009..2341422 (+)	414	WP_001643743.1	hypothetical protein	-
NB630_RS11305 (NB630_11305)	-	2341611..2342597 (-)	987	WP_001014423.1	aromatic acid exporter family protein	-
NB630_RS11310 (NB630_11310)	map	2343353..2344111 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NB630_RS11315 (NB630_11315)	-	2344328..2344714 (+)	387	WP_001110178.1	hypothetical protein	-
NB630_RS11320 (NB630_11320)	liaF	2344729..2345430 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NB630_RS11325 (NB630_11325)	vraS	2345427..2346470 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NB630_RS11330 (NB630_11330)	vraR	2346460..2347089 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
NB630_RS11335 (NB630_11335)	-	2347202..2348419 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
NB630_RS11340 (NB630_11340)	-	2348697..2348972 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
NB630_RS11345 (NB630_11345)	-	2348979..2349443 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
NB630_RS11350 (NB630_11350)	-	2349590..2349790 (+)	201	WP_000180460.1	DUF1128 family protein	-
NB630_RS11355 (NB630_11355)	-	2349793..2351049 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=694807 NB630_RS11325 WP_001017131.1 2345427..2346470(+) (vraS) [Staphylococcus aureus strain N4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=694807 NB630_RS11325 WP_001017131.1 2345427..2346470(+) (vraS) [Staphylococcus aureus strain N4]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1