Detailed information NTG0069440

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SR187_RS02360
• Genome accession: NZ_AP018400
• Coordinates: 455596..457818 (-)
• Length: 740 a.a.
• NCBI ID: WP_120171386.1
• Uniprot ID: -
• Organism: Streptococcus ruminantium strain GUT-187
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 450596..462818

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SR187_RS02345 (SR187_2395)	-	452771..454351 (-)	1581	WP_120171385.1	YSIRK-type signal peptide-containing protein	-
SR187_RS02350 (SR187_2400)	-	454542..454850 (-)	309	WP_024532451.1	DUF1827 family protein	-
SR187_RS02355 (SR187_2405)	-	454941..455402 (-)	462	WP_024532452.1	NUDIX hydrolase	-
SR187_RS02360 (SR187_2410)	clpE	455596..457818 (-)	2223	WP_120171386.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SR187_RS02365 (SR187_2415)	-	458047..458277 (+)	231	WP_024532454.1	DUF1797 family protein	-
SR187_RS02370 (SR187_2420)	-	458403..459092 (+)	690	WP_120171387.1	amino acid ABC transporter permease	-
SR187_RS02375 (SR187_2425)	-	459085..459819 (+)	735	WP_120171388.1	amino acid ABC transporter ATP-binding protein	-
SR187_RS02380 (SR187_2430)	-	460007..460855 (+)	849	WP_120171389.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
SR187_RS02385 (SR187_2435)	-	461353..462261 (-)	909	WP_120171390.1	neutral zinc metallopeptidase	-

Sequence

Protein

• Length: 740 a.a.
• Molecular weight: 82392.71 Da
• Isoelectric Point: 5.3516

>NTDB_id=69440 SR187_RS02360 WP_120171386.1 455596..457818(-) (clpE) [Streptococcus ruminantium strain GUT-187]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDMVNPNNMDPFSEFFNHLGGYPGNTPAGKKR
EQTPPTQSGGSHNGRGGQTPPPQQPNGLLEEFGINVTDIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGVGK
TAVVEGLAQKIVDGDVPQKLRGKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGDGN
MDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQSKYQDYHHVKYSDTAIEAA
AVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPREIDQRLLDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQKAT
ISEEDTPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLINLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGSFL
FVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAIAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEIEKA
HPDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGASIEGRTQSVLGQLSNFFTPEFMNRFDGII
EFQPLSKENLLEIVSLMLEDVNQRLSHNGINLHITDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLENPSEKN
LRAVMTSKGTIQIKAQTKTK

Nucleotide

• Length: 2223 bp

>NTDB_id=69440 SR187_RS02360 WP_120171386.1 455596..457818(-) (clpE) [Streptococcus ruminantium strain GUT-187]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTATACCAATCTAAACGGTAAACAGCAACAGGTTGA
CCTCTGTCACAATTGTTATCAAATCATGAAAACAGATCCAAATAATGCTATCCTACGCGGCTTAGGTGACATGGTAAATC
CTAATAATATGGATCCATTTAGCGAGTTCTTCAATCATCTGGGAGGCTATCCAGGTAATACACCTGCTGGCAAAAAACGT
GAACAGACCCCTCCAACTCAGTCTGGCGGAAGTCACAATGGTCGTGGTGGGCAGACGCCTCCTCCACAACAGCCCAATGG
TCTCTTGGAAGAATTTGGAATCAATGTGACCGATATTGCTCGCCGAGGCGACATTGACCCAGTAATTGGTCGCGATCAAG
AAATTACACGGGTCATTGAGATTCTCAACCGCAGGACCAAAAACAATCCCGTCCTCATCGGAGAGCCAGGTGTGGGTAAG
ACTGCGGTTGTTGAAGGTCTAGCTCAAAAAATCGTTGACGGTGATGTTCCACAAAAACTGCGAGGAAAAGAGGTTATCCG
ACTCGATGTGGTAAGTTTGGTCCAAGGGACAGGCATTCGCGGGCAATTTGAAGAACGGATGCAAAAACTGATGGAAGAAA
TCCGCAACCGCCGGGAAATCATCCTCTTTATTGATGAGATCCATGAAATCGTCGGAGCTGGTTCTGCCGGTGATGGTAAT
ATGGATGCAGGAAACATTCTCAAGCCAGCTTTGGCTCGTGGGGAAATGCAATTAGTAGGGGCAACCACCCTCAACGAATA
CCGCATCATTGAGAAGGATGCTGCTCTTGAACGACGCATGCAACCAGTAAAAGTAGAAGAACCTAGCGTTGAAGAAACAA
TCACCATTCTCAAGGGTATTCAAAGCAAATACCAAGATTATCACCACGTTAAGTATTCAGATACGGCCATTGAAGCTGCA
GCTGTTCTTTCCAATCGCTATATTCAAGACCGCTTTCTACCAGACAAGGCCATTGACCTACTGGACGAAGCCGGCTCCAA
AATGAACCTGACCCTCAACTTTGTTGACCCAAGGGAAATTGATCAGCGCTTGCTTGACGCTGAGAATCGTAAGGCTCAAG
CCACACGTGACGAAGATTATGAAAAAGCAGCTTATTTCCGCGATCAGATTGCAAAGTATAAGGAAATGCAAAAGGCTACC
ATCAGCGAAGAAGATACACCGCTCATTACCGAAAAAGAAATCGAAGCCATTGTCGAGCAAAAGACCAATATCCCCGTTGG
TGATTTGAAAGAAAAAGAACAATCACAGCTCATCAATCTAGCAAGCGATCTAAAAGCGCATGTTATCGGTCAAGATGAGG
CCGTTGATAAGATTGCAAAGGCTATCCGCCGTAATCGTGTCGGTCTGGGAGCACCAAATCGCCCAATCGGCTCCTTCCTC
TTTGTTGGTCCGACTGGCGTCGGAAAAACAGAATTGTCCAAACAACTCGCCATTGAACTCTTTGGATCGGCGGACAGTAT
GATTCGCTTTGATATGTCCGAATACATGGAAAAACACGCTATTGCCAAGTTAGTCGGGGCACCCCCAGGCTATGTCGGTT
ATGAAGAAGCAGGACAACTAACAGAAAAAGTTCGCCGCAATCCTTATTCACTCATCCTCTTAGATGAGATAGAAAAGGCC
CATCCGGATGTCTTACACATGTTCCTCCAAGTCTTGGATGATGGACGCTTGACAGACGGACAAGGACGGACAGTCAGCTT
TAAAGACACCATCATCATCATGACGTCCAATGCGGGAACAGGTAAGGTTGAAGCCAGCGTTGGTTTTGGTGCCAGCATAG
AAGGACGGACACAATCTGTCCTCGGTCAACTCAGCAACTTCTTTACCCCAGAGTTCATGAATCGTTTTGATGGGATTATC
GAATTCCAACCGCTCAGCAAGGAAAATCTACTAGAAATCGTCAGCCTCATGTTGGAGGATGTCAACCAGCGGCTTTCTCA
CAACGGTATCAACCTACATATCACAGATAAGGTCAAGGAAAAATTGGTTGACTTGGGCTACGACCCAAAAATGGGAGCTC
GTCCGCTTCGCCGAACTATCCAAGATCAAATTGAGGACGCTATTACTGATTTTTATCTGGAAAATCCAAGTGAAAAGAAC
CTGCGAGCAGTCATGACGAGCAAGGGAACTATCCAAATCAAGGCTCAAACAAAAACCAAATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (289-387)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (645-720)

• AAA domain (Cdc48 subfamily) (AAA_2) (474-637)

• ATPase family associated with various cellular activities (AAA) (AAA) (151-270)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	82.157	100	0.834
clpE	Streptococcus pneumoniae D39	82.157	100	0.834
clpE	Streptococcus pneumoniae R6	82.157	100	0.834
clpE	Streptococcus pneumoniae TIGR4	82.157	100	0.834
clpE	Streptococcus mutans UA159	81.551	100	0.824
clpC	Lactococcus lactis subsp. cremoris KW2	77.317	97.703	0.755
clpC	Bacillus subtilis subsp. subtilis str. 168	50.744	90.811	0.461
clpC	Streptococcus thermophilus LMD-9	47.656	86.486	0.412
clpC	Streptococcus thermophilus LMG 18311	47.344	86.486	0.409
clpC	Streptococcus pneumoniae TIGR4	47.68	84.459	0.403
clpC	Streptococcus pneumoniae Rx1	47.68	84.459	0.403
clpC	Streptococcus pneumoniae D39	47.68	84.459	0.403
clpC	Streptococcus mutans UA159	47.512	84.189	0.4
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.08	84.459	0.389