Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   OTB22_RS00810 Genome accession   NZ_CP113267
Coordinates   155872..157821 (+) Length   649 a.a.
NCBI ID   WP_268217983.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain BC2     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 150872..162821
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS00785 (OTB22_00790) - 151675..152208 (+) 534 WP_000729031.1 hypothetical protein -
  OTB22_RS00790 (OTB22_00795) nrdI 152286..152756 (+) 471 WP_000849621.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  OTB22_RS00795 (OTB22_00800) - 153049..154311 (-) 1263 WP_000075789.1 NRAMP family divalent metal transporter -
  OTB22_RS00800 (OTB22_00805) - 154621..155079 (-) 459 WP_000745055.1 DUF3021 domain-containing protein -
  OTB22_RS00805 (OTB22_00810) brsR 155076..155516 (-) 441 WP_000861967.1 LytTR family DNA-binding domain-containing protein Regulator
  OTB22_RS00810 (OTB22_00815) hexB 155872..157821 (+) 1950 WP_268217983.1 DNA mismatch repair endonuclease MutL Machinery gene
  OTB22_RS00815 (OTB22_00820) ribE 158146..158613 (-) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  OTB22_RS00820 (OTB22_00825) - 158614..159819 (-) 1206 WP_000456639.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  OTB22_RS00825 (OTB22_00830) ribE 159839..160474 (-) 636 WP_000493845.1 riboflavin synthase -
  OTB22_RS00830 (OTB22_00835) ribD 160459..161559 (-) 1101 WP_001284091.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  OTB22_RS00835 (OTB22_00840) ruvA 161964..162557 (+) 594 WP_000271487.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73490.01 Da        Isoelectric Point: 5.3770

>NTDB_id=690602 OTB22_RS00810 WP_268217983.1 155872..157821(+) (hexB) [Streptococcus pneumoniae strain BC2]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKIQITDNGYGISHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKKVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=690602 OTB22_RS00810 WP_268217983.1 155872..157821(+) (hexB) [Streptococcus pneumoniae strain BC2]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCGGCTGGAGAGGTCATTGAACGCCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGTTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AAATCCAAATCACAGATAACGGTTATGGAATTTCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGTGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTCGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGTCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGAAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

99.384

100

0.994