Detailed information NTG0068992

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPYKS030_RS03805
• Genome accession: NZ_AP018337
• Coordinates: 688230..689267 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain KS030
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 683230..694267

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYKS030_RS03780 (SPYKS030_06810)	-	683494..684825 (+)	1332	WP_011054719.1	dipeptidase	-
SPYKS030_RS03785 (SPYKS030_06820)	arcC	684845..685795 (+)	951	WP_003051912.1	carbamate kinase	-
SPYKS030_RS03790 (SPYKS030_06830)	asnA	686108..687100 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
SPYKS030_RS03795 (SPYKS030_06840)	rsmD	687223..687762 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPYKS030_RS03800 (SPYKS030_06850)	coaD	687752..688243 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SPYKS030_RS03805 (SPYKS030_06860)	sepM	688230..689267 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SPYKS030_RS03810 (SPYKS030_06870)	-	689681..690658 (+)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
SPYKS030_RS03815 (SPYKS030_06880)	-	691106..691726 (+)	621	WP_002992791.1	YutD family protein	-
SPYKS030_RS03820 (SPYKS030_06890)	rlmN	691730..692809 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SPYKS030_RS03825 (SPYKS030_06900)	-	692891..693517 (-)	627	WP_002989076.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=68992 SPYKS030_RS03805 WP_010922499.1 688230..689267(+) (sepM) [Streptococcus pyogenes strain KS030]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=68992 SPYKS030_RS03805 WP_010922499.1 688230..689267(+) (sepM) [Streptococcus pyogenes strain KS030]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693