Detailed information NTG0689844

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M8Z95_RS04170
• Genome accession: NZ_CP097519
• Coordinates: 898894..899940 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain C066
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 893894..904940

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M8Z95_RS04145 (M8Z95_04145)	-	895035..895571 (+)	537	WP_001830372.1	hypothetical protein	-
M8Z95_RS04150 (M8Z95_04150)	-	895722..896708 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
M8Z95_RS04155 (M8Z95_04155)	map	896882..897637 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
M8Z95_RS04160 (M8Z95_04160)	-	897795..898181 (+)	387	WP_001830382.1	hypothetical protein	-
M8Z95_RS04165 (M8Z95_04165)	liaF	898196..898897 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
M8Z95_RS04170 (M8Z95_04170)	vraS	898894..899940 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
M8Z95_RS04175 (M8Z95_04175)	vraR	899930..900559 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
M8Z95_RS04180 (M8Z95_04180)	-	900616..901794 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
M8Z95_RS04185 (M8Z95_04185)	-	902201..902485 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
M8Z95_RS04190 (M8Z95_04190)	-	902493..902957 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
M8Z95_RS04195 (M8Z95_04195)	-	903098..903313 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
M8Z95_RS04200 (M8Z95_04200)	-	903315..904556 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=689844 M8Z95_RS04170 WP_001830374.1 898894..899940(+) (vraS) [Staphylococcus epidermidis strain C066]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=689844 M8Z95_RS04170 WP_001830374.1 898894..899940(+) (vraS) [Staphylococcus epidermidis strain C066]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92