Detailed information NTG0689773

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M8Z31_RS04660
• Genome accession: NZ_CP097512
• Coordinates: 992909..993955 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain C019
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 987909..998955

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M8Z31_RS04635 (M8Z31_04635)	-	989050..989586 (+)	537	WP_002470337.1	hypothetical protein	-
M8Z31_RS04640 (M8Z31_04640)	-	989737..990723 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
M8Z31_RS04645 (M8Z31_04645)	map	990897..991652 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
M8Z31_RS04650 (M8Z31_04650)	-	991810..992196 (+)	387	WP_001830382.1	hypothetical protein	-
M8Z31_RS04655 (M8Z31_04655)	liaF	992211..992912 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
M8Z31_RS04660 (M8Z31_04660)	vraS	992909..993955 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
M8Z31_RS04665 (M8Z31_04665)	vraR	993945..994574 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
M8Z31_RS04670 (M8Z31_04670)	-	994631..995809 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
M8Z31_RS04675 (M8Z31_04675)	-	996216..996500 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
M8Z31_RS04680 (M8Z31_04680)	-	996508..996972 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
M8Z31_RS04685 (M8Z31_04685)	-	997113..997328 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
M8Z31_RS04690 (M8Z31_04690)	-	997330..998571 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=689773 M8Z31_RS04660 WP_001830374.1 992909..993955(+) (vraS) [Staphylococcus epidermidis strain C019]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=689773 M8Z31_RS04660 WP_001830374.1 992909..993955(+) (vraS) [Staphylococcus epidermidis strain C019]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92