Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   M8Z31_RS00205 Genome accession   NZ_CP097512
Coordinates   48572..49921 (-) Length   449 a.a.
NCBI ID   WP_000815640.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain C019     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 9755..55092 48572..49921 within 0


Gene organization within MGE regions


Location: 9755..55092
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M8Z31_RS00040 (M8Z31_00040) - 11449..12648 (-) 1200 WP_284041105.1 IS110-like element ISSep2 family transposase -
  M8Z31_RS00045 (M8Z31_00045) - 13098..13913 (-) 816 WP_001831762.1 NAD(P)H-hydrate dehydratase -
  M8Z31_RS00050 (M8Z31_00050) serS 14758..16044 (+) 1287 WP_002455928.1 serine--tRNA ligase -
  M8Z31_RS00055 (M8Z31_00055) sph 16574..17557 (-) 984 WP_002470131.1 sphingomyelin phosphodiesterase -
  M8Z31_RS00060 (M8Z31_00060) - 17942..18634 (+) 693 WP_002447637.1 AzlC family ABC transporter permease -
  M8Z31_RS00065 (M8Z31_00065) - 18631..18960 (+) 330 WP_002456807.1 AzlD domain-containing protein -
  M8Z31_RS00070 (M8Z31_00070) - 19250..20218 (+) 969 WP_001831747.1 alpha/beta fold hydrolase -
  M8Z31_RS00075 (M8Z31_00075) - 20466..21392 (+) 927 WP_002494609.1 DUF2232 domain-containing protein -
  M8Z31_RS00080 (M8Z31_00080) - 21421..23388 (+) 1968 WP_002470520.1 DHH family phosphoesterase -
  M8Z31_RS00085 (M8Z31_00085) rplI 23385..23831 (+) 447 WP_001831811.1 50S ribosomal protein L9 -
  M8Z31_RS00090 (M8Z31_00090) dnaB 24002..25402 (+) 1401 WP_001831779.1 replicative DNA helicase -
  M8Z31_RS00095 (M8Z31_00095) - 25681..26964 (+) 1284 WP_002455931.1 adenylosuccinate synthase -
  M8Z31_RS00110 (M8Z31_00110) yycF 28017..28718 (+) 702 WP_001831816.1 response regulator YycF -
  M8Z31_RS00115 (M8Z31_00115) walK 28731..30563 (+) 1833 WP_002437327.1 cell wall metabolism sensor histidine kinase WalK -
  M8Z31_RS00120 (M8Z31_00120) - 30556..31893 (+) 1338 WP_002447630.1 YycH family regulatory protein -
  M8Z31_RS00125 (M8Z31_00125) yycI 31894..32685 (+) 792 WP_002467996.1 two-component system regulatory protein YycI -
  M8Z31_RS00130 (M8Z31_00130) - 33306..34106 (+) 801 WP_002447628.1 MBL fold metallo-hydrolase -
  M8Z31_RS00135 (M8Z31_00135) rlmH 35161..35640 (+) 480 WP_002484627.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M8Z31_RS00140 (M8Z31_00140) - 35962..37218 (+) 1257 WP_000566670.1 DUF3578 domain-containing protein -
  M8Z31_RS00145 (M8Z31_00145) - 37633..37872 (+) 240 WP_001282728.1 hypothetical protein -
  M8Z31_RS00150 (M8Z31_00150) - 37904..38578 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  M8Z31_RS00155 (M8Z31_00155) - 38843..39586 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  M8Z31_RS00160 (M8Z31_00160) - 39683..40111 (+) 429 WP_000872606.1 MaoC family dehydratase -
  M8Z31_RS00165 (M8Z31_00165) mecA 40157..42166 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  M8Z31_RS00170 (M8Z31_00170) - 42263..43249 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  M8Z31_RS00175 (M8Z31_00175) - 43221..43481 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  M8Z31_RS00180 (M8Z31_00180) - 43472..45079 (-) 1608 Protein_33 IS1182 family transposase -
  M8Z31_RS00185 (M8Z31_00185) - 45131..45637 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  M8Z31_RS00190 (M8Z31_00190) - 45652..45963 (-) 312 WP_000700851.1 DUF960 family protein -
  M8Z31_RS00195 (M8Z31_00195) - 46050..46400 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  M8Z31_RS00200 (M8Z31_00200) ccrB 46922..48550 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  M8Z31_RS00205 (M8Z31_00205) ccrA 48572..49921 (-) 1350 WP_000815640.1 recombinase family protein Machinery gene
  M8Z31_RS00210 (M8Z31_00210) - 50155..51948 (-) 1794 WP_000079473.1 DUF927 domain-containing protein -
  M8Z31_RS00215 (M8Z31_00215) - 51948..52244 (-) 297 WP_000273823.1 single-stranded DNA-binding protein -
  M8Z31_RS00220 (M8Z31_00220) - 52437..53483 (-) 1047 WP_001042023.1 hypothetical protein -
  M8Z31_RS00225 (M8Z31_00225) - 53938..55092 (+) 1155 WP_000912116.1 ATP-binding protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52663.34 Da        Isoelectric Point: 9.9639

>NTDB_id=689765 M8Z31_RS00205 WP_000815640.1 48572..49921(-) (ccrA) [Staphylococcus epidermidis strain C019]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=689765 M8Z31_RS00205 WP_000815640.1 48572..49921(-) (ccrA) [Staphylococcus epidermidis strain C019]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.947

100

0.759