Detailed information NTG0688045

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: M3N36_RS06935
• Genome accession: NZ_CP097251
• Coordinates: 1342056..1343093 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain 21SPY7071 isolate cerebral abscess
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1337056..1348093

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M3N36_RS06915 (M3N36_06915)	-	1337806..1338432 (+)	627	WP_002989076.1	A24 family peptidase	-
M3N36_RS06920 (M3N36_06920)	rlmN	1338514..1339594 (-)	1081	Protein_1341	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
M3N36_RS06925 (M3N36_06925)	-	1339598..1340218 (-)	621	WP_002992791.1	YutD family protein	-
M3N36_RS06930 (M3N36_06930)	-	1340666..1341642 (-)	977	Protein_1343	LacI family DNA-binding transcriptional regulator	-
M3N36_RS06935 (M3N36_06935)	sepM	1342056..1343093 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
M3N36_RS06940 (M3N36_06940)	coaD	1343080..1343571 (-)	492	WP_030127407.1	pantetheine-phosphate adenylyltransferase	-
M3N36_RS06945 (M3N36_06945)	rsmD	1343561..1344100 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
M3N36_RS06950 (M3N36_06950)	asnA	1344223..1345215 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
M3N36_RS06955 (M3N36_06955)	arcC	1345528..1346478 (-)	951	WP_010922501.1	carbamate kinase	-
M3N36_RS06960 (M3N36_06960)	-	1346498..1347829 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=688045 M3N36_RS06935 WP_002983824.1 1342056..1343093(-) (sepM) [Streptococcus pyogenes strain 21SPY7071 isolate cerebral abscess]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=688045 M3N36_RS06935 WP_002983824.1 1342056..1343093(-) (sepM) [Streptococcus pyogenes strain 21SPY7071 isolate cerebral abscess]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGGAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGTGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69