Detailed information NTG0687253

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M3M41_RS09510
• Genome accession: NZ_CP097115
• Coordinates: 1927220..1928263 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JP18270
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1922220..1933263

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M3M41_RS09480 (M3M41_09475)	-	1922638..1923894 (-)	1257	WP_001795438.1	aminopeptidase	-
M3M41_RS09485 (M3M41_09480)	-	1923897..1924097 (-)	201	WP_000180461.1	DUF1128 family protein	-
M3M41_RS09490 (M3M41_09485)	-	1924244..1924708 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M3M41_RS09495 (M3M41_09490)	-	1924715..1924990 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M3M41_RS09500 (M3M41_09495)	-	1925268..1926485 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
M3M41_RS09505 (M3M41_09500)	vraR	1926601..1927230 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
M3M41_RS09510 (M3M41_09505)	vraS	1927220..1928263 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M3M41_RS09515 (M3M41_09510)	liaF	1928260..1928961 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M3M41_RS09520 (M3M41_09515)	-	1928976..1929362 (-)	387	WP_001110179.1	hypothetical protein	-
M3M41_RS09525 (M3M41_09520)	map	1929579..1930337 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
M3M41_RS09530 (M3M41_09525)	-	1930865..1931851 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
M3M41_RS09535 (M3M41_09530)	-	1932282..1932695 (-)	414	WP_001549145.1	hypothetical protein	-
M3M41_RS09540 (M3M41_09535)	-	1932724..1932834 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=687253 M3M41_RS09510 WP_001017131.1 1927220..1928263(-) (vraS) [Staphylococcus aureus strain JP18270]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=687253 M3M41_RS09510 WP_001017131.1 1927220..1928263(-) (vraS) [Staphylococcus aureus strain JP18270]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1