Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   KK0981_RS00310 Genome accession   NZ_AP017971
Coordinates   51342..52691 (+) Length   449 a.a.
NCBI ID   WP_000801609.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain KK0981     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 12180..62796 51342..52691 within 0


Gene organization within MGE regions


Location: 12180..62796
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KK0981_RS00060 (KK0981_00130) ftsH 12180..14138 (+) 1959 WP_050209888.1 ATP-dependent zinc metalloprotease FtsH -
  KK0981_RS00065 (KK0981_00140) comX/comX2 14260..14739 (+) 480 WP_000588897.1 sigma-70 family RNA polymerase sigma factor Regulator
  KK0981_RS00100 - 20242..21080 (+) 839 Protein_14 IS630 family transposase -
  KK0981_RS00105 - 21115..21912 (-) 798 Protein_15 transposase -
  KK0981_RS00110 (KK0981_00240) comW 22178..22414 (+) 237 WP_000939548.1 sigma(X)-activator ComW Regulator
  KK0981_RS00115 (KK0981_00250) - 22645..23931 (+) 1287 WP_000205044.1 adenylosuccinate synthase -
  KK0981_RS00120 (KK0981_00260) tadA 24132..24599 (+) 468 WP_000291875.1 tRNA adenosine(34) deaminase TadA -
  KK0981_RS00130 (KK0981_00270) - 24939..26195 (+) 1257 WP_096376093.1 ISL3 family transposase -
  KK0981_RS00135 (KK0981_00280) - 26264..27400 (-) 1137 WP_001824497.1 tyrosine-type recombinase/integrase -
  KK0981_RS00140 (KK0981_00290) - 27461..28531 (-) 1071 WP_000401841.1 type I restriction endonuclease -
  KK0981_RS11600 - 28548..28924 (-) 377 Protein_22 ImmA/IrrE family metallo-endopeptidase -
  KK0981_RS00150 (KK0981_00320) - 28937..29200 (-) 264 WP_000285962.1 type II toxin-antitoxin system RelE family toxin -
  KK0981_RS00155 (KK0981_00330) - 29200..29433 (-) 234 WP_000156419.1 hypothetical protein -
  KK0981_RS00160 (KK0981_00340) - 29433..29801 (-) 369 WP_000464160.1 helix-turn-helix domain-containing protein -
  KK0981_RS00165 (KK0981_00360) - 30215..30454 (-) 240 WP_000142893.1 hypothetical protein -
  KK0981_RS00170 (KK0981_00370) - 30519..30710 (+) 192 WP_001112859.1 DNA-binding protein -
  KK0981_RS00175 (KK0981_00380) - 30733..30936 (+) 204 WP_001247549.1 hypothetical protein -
  KK0981_RS00180 (KK0981_00400) - 31091..31258 (-) 168 WP_000024180.1 YjzC family protein -
  KK0981_RS00185 (KK0981_00410) - 31263..31643 (+) 381 Protein_30 autolysin -
  KK0981_RS00190 (KK0981_00420) - 31927..32370 (+) 444 WP_000701992.1 dUTP diphosphatase -
  KK0981_RS00195 (KK0981_00430) - 32372..32887 (+) 516 WP_001842035.1 histidine phosphatase family protein -
  KK0981_RS00200 (KK0981_00440) radA 32901..34262 (+) 1362 WP_074017595.1 DNA repair protein RadA Machinery gene
  KK0981_RS00205 (KK0981_00450) - 34335..34832 (+) 498 WP_001809263.1 beta-class carbonic anhydrase -
  KK0981_RS00215 (KK0981_00470) - 34857..35671 (+) 815 Protein_35 PrsW family intramembrane metalloprotease -
  KK0981_RS00220 (KK0981_00480) - 35816..36784 (+) 969 WP_000010163.1 ribose-phosphate diphosphokinase -
  KK0981_RS00225 - 36921..37199 (-) 279 Protein_37 transposase family protein -
  KK0981_RS12130 - 37326..38233 (-) 908 Protein_38 Rpn family recombination-promoting nuclease/putative transposase -
  KK0981_RS00245 (KK0981_00520) polA 38489..41122 (+) 2634 WP_002202064.1 DNA polymerase I -
  KK0981_RS00250 (KK0981_00530) - 41207..41644 (+) 438 WP_000076487.1 CoA-binding protein -
  KK0981_RS12135 - 41685..41855 (+) 171 WP_050111560.1 hypothetical protein -
  KK0981_RS00260 (KK0981_00540) - 41874..42884 (-) 1011 WP_000009170.1 YeiH family protein -
  KK0981_RS00265 (KK0981_00550) - 43033..44202 (+) 1170 WP_000366342.1 pyridoxal phosphate-dependent aminotransferase -
  KK0981_RS00270 (KK0981_00560) recO 44199..44969 (+) 771 WP_000616172.1 DNA repair protein RecO -
  KK0981_RS00275 (KK0981_00570) plsX 44966..45958 (+) 993 WP_000717458.1 phosphate acyltransferase PlsX -
  KK0981_RS00280 (KK0981_00580) - 45964..46197 (+) 234 WP_000136447.1 acyl carrier protein -
  KK0981_RS00285 (KK0981_00590) - 46234..46533 (+) 300 Protein_47 transposase family protein -
  KK0981_RS00290 (KK0981_00600) blpU 46736..46966 (+) 231 WP_001093069.1 bacteriocin-like peptide BlpU -
  KK0981_RS12565 - 46969..47094 (+) 126 WP_001842754.1 PncF family bacteriocin immunity protein -
  KK0981_RS00295 - 47418..48744 (-) 1327 Protein_50 ISL3 family transposase -
  KK0981_RS00305 (KK0981_00640) comA 49176..51329 (+) 2154 WP_000668297.1 peptide cleavage/export ABC transporter ComA Regulator
  KK0981_RS00310 (KK0981_00650) comB 51342..52691 (+) 1350 WP_000801609.1 competence pheromone export protein ComB Regulator
  KK0981_RS00315 (KK0981_00660) purC 52861..53568 (+) 708 WP_000043302.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  KK0981_RS12640 - 53579..53713 (+) 135 WP_000429436.1 hypothetical protein -
  KK0981_RS00325 (KK0981_00670) - 53770..57495 (+) 3726 WP_000361219.1 phosphoribosylformylglycinamidine synthase -
  KK0981_RS00330 (KK0981_00680) purF 57588..59030 (+) 1443 WP_000220636.1 amidophosphoribosyltransferase -
  KK0981_RS00335 (KK0981_00690) purM 59067..60089 (+) 1023 WP_096376094.1 phosphoribosylformylglycinamidine cyclo-ligase -
  KK0981_RS00340 (KK0981_00700) purN 60086..60631 (+) 546 WP_000717501.1 phosphoribosylglycinamide formyltransferase -
  KK0981_RS00345 (KK0981_20950) - 60715..61224 (+) 510 WP_000894018.1 VanZ family protein -
  KK0981_RS00350 (KK0981_20960) purH 61249..62796 (+) 1548 WP_000167076.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49579.48 Da        Isoelectric Point: 5.3895

>NTDB_id=68663 KK0981_RS00310 WP_000801609.1 51342..52691(+) (comB) [Streptococcus pneumoniae strain KK0981]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQIKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=68663 KK0981_RS00310 WP_000801609.1 51342..52691(+) (comB) [Streptococcus pneumoniae strain KK0981]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCCAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAAGAAAATCCCCAAATTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACATTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae TIGR4

99.332

100

0.993
  comB Streptococcus pneumoniae D39

99.109

100

0.991
  comB Streptococcus pneumoniae R6

99.109

100

0.991
  comB Streptococcus pneumoniae Rx1

99.109

100

0.991
  comB Streptococcus mitis SK321

95.1

100

0.951
  comB Streptococcus mitis NCTC 12261

94.655

100

0.947
  comB Streptococcus gordonii str. Challis substr. CH1

55.556

100

0.557

Multiple sequence alignment