Detailed information NTG0068230

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: JMUB1235_RS05880
• Genome accession: NZ_AP017629
• Coordinates: 1163059..1164096 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain JMUB1235
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1158059..1169096

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMUB1235_RS05860	-	1158801..1159427 (+)	627	WP_002983834.1	prepilin peptidase	-
JMUB1235_RS05865 (JMUB1235_1169)	rlmN	1159509..1160588 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
JMUB1235_RS05870 (JMUB1235_1170)	-	1160592..1161212 (-)	621	WP_002992791.1	YutD family protein	-
JMUB1235_RS05875 (JMUB1235_1171)	-	1161660..1162637 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
JMUB1235_RS05880 (JMUB1235_1172)	sepM	1163059..1164096 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
JMUB1235_RS05885 (JMUB1235_1173)	coaD	1164083..1164574 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
JMUB1235_RS05890 (JMUB1235_1174)	rsmD	1164564..1165103 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
JMUB1235_RS05895 (JMUB1235_1175)	asnA	1165226..1166218 (-)	993	WP_096466738.1	aspartate--ammonia ligase	-
JMUB1235_RS05900 (JMUB1235_1176)	arcC	1166531..1167481 (-)	951	WP_010922501.1	carbamate kinase	-
JMUB1235_RS05905 (JMUB1235_1177)	-	1167501..1168832 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=68230 JMUB1235_RS05880 WP_010922499.1 1163059..1164096(-) (sepM) [Streptococcus pyogenes strain JMUB1235]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=68230 JMUB1235_RS05880 WP_010922499.1 1163059..1164096(-) (sepM) [Streptococcus pyogenes strain JMUB1235]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693