Detailed information NTG0681623

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F48_RS10460
• Genome accession: NZ_CP096532
• Coordinates: 2084849..2085892 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M083782
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2079849..2090892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F48_RS10430 (M1F48_10405)	-	2080270..2081526 (-)	1257	WP_074347694.1	aminopeptidase	-
M1F48_RS10435 (M1F48_10410)	-	2081529..2081729 (-)	201	WP_000180460.1	DUF1128 family protein	-
M1F48_RS10440 (M1F48_10415)	-	2081876..2082340 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F48_RS10445 (M1F48_10420)	-	2082347..2082622 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F48_RS10450 (M1F48_10425)	-	2082900..2084117 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F48_RS10455 (M1F48_10430)	vraR	2084230..2084859 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F48_RS10460 (M1F48_10435)	vraS	2084849..2085892 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F48_RS10465 (M1F48_10440)	liaF	2085889..2086590 (-)	702	WP_000149063.1	cell wall-active antibiotics response protein LiaF	-
M1F48_RS10470 (M1F48_10445)	-	2086605..2086991 (-)	387	WP_001110182.1	hypothetical protein	-
M1F48_RS10475 (M1F48_10450)	map	2087208..2087966 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F48_RS10480 (M1F48_10455)	-	2088550..2089536 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F48_RS10485 (M1F48_10460)	-	2089725..2090138 (-)	414	WP_025174370.1	hypothetical protein	-
M1F48_RS10490 (M1F48_10465)	-	2090167..2090277 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681623 M1F48_RS10460 WP_001017131.1 2084849..2085892(-) (vraS) [Staphylococcus aureus strain RIVM_M083782]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681623 M1F48_RS10460 WP_001017131.1 2084849..2085892(-) (vraS) [Staphylococcus aureus strain RIVM_M083782]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1