Detailed information NTG0681579

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F49_RS10155
• Genome accession: NZ_CP096530
• Coordinates: 2034678..2035721 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M084526
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2029678..2040721

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F49_RS10125 (M1F49_10120)	-	2030099..2031355 (-)	1257	WP_074347694.1	aminopeptidase	-
M1F49_RS10130 (M1F49_10125)	-	2031358..2031558 (-)	201	WP_000180460.1	DUF1128 family protein	-
M1F49_RS10135 (M1F49_10130)	-	2031705..2032169 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F49_RS10140 (M1F49_10135)	-	2032176..2032451 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F49_RS10145 (M1F49_10140)	-	2032729..2033946 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F49_RS10150 (M1F49_10145)	vraR	2034059..2034688 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F49_RS10155 (M1F49_10150)	vraS	2034678..2035721 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F49_RS10160 (M1F49_10155)	liaF	2035718..2036419 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M1F49_RS10165 (M1F49_10160)	-	2036434..2036820 (-)	387	WP_001110182.1	hypothetical protein	-
M1F49_RS10170 (M1F49_10165)	map	2037037..2037795 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F49_RS10175 (M1F49_10170)	-	2038379..2039365 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F49_RS10180 (M1F49_10175)	-	2039554..2039967 (-)	414	WP_025174370.1	hypothetical protein	-
M1F49_RS10185 (M1F49_10180)	-	2039996..2040106 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681579 M1F49_RS10155 WP_001017131.1 2034678..2035721(-) (vraS) [Staphylococcus aureus strain RIVM_M084526]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681579 M1F49_RS10155 WP_001017131.1 2034678..2035721(-) (vraS) [Staphylococcus aureus strain RIVM_M084526]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1