Detailed information NTG0681458

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F51_RS03720
• Genome accession: NZ_CP096526
• Coordinates: 760345..761388 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M087195
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 755345..766388

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F51_RS03690 (M1F51_03670)	-	755960..756070 (+)	111	WP_014937049.1	hypothetical protein	-
M1F51_RS03695 (M1F51_03675)	-	756099..756512 (+)	414	WP_025174370.1	hypothetical protein	-
M1F51_RS03700 (M1F51_03680)	-	756701..757687 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F51_RS03705 (M1F51_03685)	map	758271..759029 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F51_RS03710 (M1F51_03690)	-	759246..759632 (+)	387	WP_001110182.1	hypothetical protein	-
M1F51_RS03715 (M1F51_03695)	liaF	759647..760348 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M1F51_RS03720 (M1F51_03700)	vraS	760345..761388 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F51_RS03725 (M1F51_03705)	vraR	761378..762007 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F51_RS03730 (M1F51_03710)	-	762120..763337 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F51_RS03735 (M1F51_03715)	-	763615..763890 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F51_RS03740 (M1F51_03720)	-	763897..764361 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F51_RS03745 (M1F51_03725)	-	764508..764708 (+)	201	WP_000180460.1	DUF1128 family protein	-
M1F51_RS03750 (M1F51_03730)	-	764711..765967 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681458 M1F51_RS03720 WP_001017131.1 760345..761388(+) (vraS) [Staphylococcus aureus strain RIVM_M087195]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681458 M1F51_RS03720 WP_001017131.1 760345..761388(+) (vraS) [Staphylococcus aureus strain RIVM_M087195]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1