Detailed information NTG0681443

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F52_RS09760
• Genome accession: NZ_CP096522
• Coordinates: 1996812..1997855 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M085090
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1991812..2002855

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F52_RS09730 (M1F52_09710)	-	1992233..1993489 (-)	1257	WP_074347694.1	aminopeptidase	-
M1F52_RS09735 (M1F52_09715)	-	1993492..1993692 (-)	201	WP_000180460.1	DUF1128 family protein	-
M1F52_RS09740 (M1F52_09720)	-	1993839..1994303 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F52_RS09745 (M1F52_09725)	-	1994310..1994585 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F52_RS09750 (M1F52_09730)	-	1994863..1996080 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F52_RS09755 (M1F52_09735)	vraR	1996193..1996822 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F52_RS09760 (M1F52_09740)	vraS	1996812..1997855 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F52_RS09765 (M1F52_09745)	liaF	1997852..1998553 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M1F52_RS09770 (M1F52_09750)	-	1998568..1998954 (-)	387	WP_001110182.1	hypothetical protein	-
M1F52_RS09775 (M1F52_09755)	map	1999171..1999929 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F52_RS09780 (M1F52_09760)	-	2000513..2001499 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F52_RS09785 (M1F52_09765)	-	2001688..2002101 (-)	414	WP_025174370.1	hypothetical protein	-
M1F52_RS09790 (M1F52_09770)	-	2002130..2002240 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681443 M1F52_RS09760 WP_001017131.1 1996812..1997855(-) (vraS) [Staphylococcus aureus strain RIVM_M085090]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681443 M1F52_RS09760 WP_001017131.1 1996812..1997855(-) (vraS) [Staphylococcus aureus strain RIVM_M085090]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1