Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   M0D62_RS00375 Genome accession   NZ_CP096114
Coordinates   50464..51813 (-) Length   449 a.a.
NCBI ID   WP_000815651.1    Uniprot ID   A0A8F2DEH1
Organism   Staphylococcus argenteus strain MRSA-139-14-168     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 42049..56973 50464..51813 within 0


Gene organization within MGE regions


Location: 42049..56973
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M0D62_RS00335 (M0D62_00335) mecA 42049..44058 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  M0D62_RS00340 (M0D62_00340) - 44155..45141 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  M0D62_RS00345 (M0D62_00345) - 45113..45373 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  M0D62_RS00350 (M0D62_00350) - 45364..46971 (-) 1608 Protein_36 IS1182 family transposase -
  M0D62_RS00355 (M0D62_00355) - 47023..47529 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  M0D62_RS00360 (M0D62_00360) - 47544..47855 (-) 312 WP_000700851.1 DUF960 family protein -
  M0D62_RS00365 (M0D62_00365) - 47942..48292 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  M0D62_RS00370 (M0D62_00370) ccrB 48814..50442 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  M0D62_RS00375 (M0D62_00375) ccrA 50464..51813 (-) 1350 WP_000815651.1 recombinase family protein Machinery gene
  M0D62_RS00380 (M0D62_00380) - 52047..53834 (-) 1788 WP_000122624.1 DUF927 domain-containing protein -
  M0D62_RS00385 (M0D62_00385) - 53834..54130 (-) 297 WP_000273825.1 single-stranded DNA-binding protein -
  M0D62_RS00390 (M0D62_00390) - 54323..55369 (-) 1047 WP_001042025.1 hypothetical protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52626.34 Da        Isoelectric Point: 10.0062

>NTDB_id=679393 M0D62_RS00375 WP_000815651.1 50464..51813(-) (ccrA) [Staphylococcus argenteus strain MRSA-139-14-168]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHILTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQAMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=679393 M0D62_RS00375 WP_000815651.1 50464..51813(-) (ccrA) [Staphylococcus argenteus strain MRSA-139-14-168]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACATATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.327

100

0.973
  ccrA Staphylococcus aureus COL

75.056

100

0.751