Detailed information NTG0675560

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA78_RS04385
• Genome accession: NZ_CP095116
• Coordinates: 897386..898429 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6156
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 892386..903429

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA78_RS04355 (MUA78_04355)	-	893114..893224 (+)	111	WP_001790257.1	hypothetical protein	-
MUA78_RS04360 (MUA78_04360)	-	893253..893666 (+)	414	WP_262515481.1	hypothetical protein	-
MUA78_RS04365 (MUA78_04365)	-	893855..894841 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUA78_RS04370 (MUA78_04370)	map	895312..896070 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA78_RS04375 (MUA78_04375)	-	896287..896673 (+)	387	WP_001110179.1	hypothetical protein	-
MUA78_RS04380 (MUA78_04380)	liaF	896688..897389 (+)	702	WP_262515386.1	cell wall-active antibiotics response protein LiaF	-
MUA78_RS04385 (MUA78_04385)	vraS	897386..898429 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA78_RS04390 (MUA78_04390)	vraR	898419..899048 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA78_RS04395 (MUA78_04395)	-	899161..900378 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA78_RS04400 (MUA78_04400)	-	900656..900931 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA78_RS04405 (MUA78_04405)	-	900938..901402 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA78_RS04410 (MUA78_04410)	-	901549..901749 (+)	201	WP_000180460.1	DUF1128 family protein	-
MUA78_RS04415 (MUA78_04415)	-	901752..903008 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=675560 MUA78_RS04385 WP_001017131.1 897386..898429(+) (vraS) [Staphylococcus aureus strain IVB6156]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=675560 MUA78_RS04385 WP_001017131.1 897386..898429(+) (vraS) [Staphylococcus aureus strain IVB6156]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1