Detailed information NTG0675545

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA55_RS10140
• Genome accession: NZ_CP095112
• Coordinates: 2041787..2042830 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6157
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2036787..2047830

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA55_RS10110 (MUA55_10115)	-	2037208..2038464 (-)	1257	WP_001793983.1	aminopeptidase	-
MUA55_RS10115 (MUA55_10120)	-	2038467..2038667 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA55_RS10120 (MUA55_10125)	-	2038814..2039278 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA55_RS10125 (MUA55_10130)	-	2039285..2039560 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA55_RS10130 (MUA55_10135)	-	2039838..2041055 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA55_RS10135 (MUA55_10140)	vraR	2041168..2041797 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA55_RS10140 (MUA55_10145)	vraS	2041787..2042830 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA55_RS10145 (MUA55_10150)	liaF	2042827..2043528 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA55_RS10150 (MUA55_10155)	-	2043543..2043929 (-)	387	WP_001110178.1	hypothetical protein	-
MUA55_RS10155 (MUA55_10160)	map	2044146..2044904 (-)	759	WP_252559258.1	type I methionyl aminopeptidase	-
MUA55_RS10160 (MUA55_10165)	-	2045660..2046646 (+)	987	WP_001014423.1	FUSC family protein	-
MUA55_RS10165 (MUA55_10170)	-	2046835..2047248 (-)	414	WP_001643743.1	hypothetical protein	-
MUA55_RS10170 (MUA55_10175)	-	2047277..2047387 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=675545 MUA55_RS10140 WP_001017131.1 2041787..2042830(-) (vraS) [Staphylococcus aureus strain IVB6157]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=675545 MUA55_RS10140 WP_001017131.1 2041787..2042830(-) (vraS) [Staphylococcus aureus strain IVB6157]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1