Detailed information NTG0675202

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUW37_RS04465
• Genome accession: NZ_CP095090
• Coordinates: 953796..954842 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain SKN25lux
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 948796..959842

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUW37_RS04440 (MUW37_04440)	-	949937..950473 (+)	537	WP_001830372.1	hypothetical protein	-
MUW37_RS04445 (MUW37_04445)	-	950624..951610 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MUW37_RS04450 (MUW37_04450)	map	951784..952539 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MUW37_RS04455 (MUW37_04455)	-	952697..953083 (+)	387	WP_001830382.1	hypothetical protein	-
MUW37_RS04460 (MUW37_04460)	liaF	953098..953799 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MUW37_RS04465 (MUW37_04465)	vraS	953796..954842 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MUW37_RS04470 (MUW37_04470)	vraR	954832..955461 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MUW37_RS04475 (MUW37_04475)	-	955518..956696 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MUW37_RS04480 (MUW37_04480)	-	957103..957387 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MUW37_RS04485 (MUW37_04485)	-	957395..957859 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MUW37_RS04490 (MUW37_04490)	-	958000..958215 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MUW37_RS04495 (MUW37_04495)	-	958217..959458 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=675202 MUW37_RS04465 WP_001830374.1 953796..954842(+) (vraS) [Staphylococcus epidermidis strain SKN25lux]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=675202 MUW37_RS04465 WP_001830374.1 953796..954842(+) (vraS) [Staphylococcus epidermidis strain SKN25lux]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92