Detailed information NTG0675118

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: MP619_RS10855
• Genome accession: NZ_CP095081
• Coordinates: 2181760..2184204 (-)
• Length: 814 a.a.
• NCBI ID: WP_129556297.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae strain WJ001
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	2179631..2191798	2181760..2184204	within	0

Gene organization within MGE regions

Location: 2179631..2191798

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MP619_RS10845 (MP619_10815)	groL	2179631..2181256 (-)	1626	WP_268227775.1	chaperonin GroEL	-
MP619_RS10850 (MP619_10820)	groES	2181292..2181582 (-)	291	WP_003054738.1	co-chaperone GroES	-
MP619_RS10855 (MP619_10825)	clpC	2181760..2184204 (-)	2445	WP_129556297.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
MP619_RS10860 (MP619_10830)	-	2184204..2184665 (-)	462	WP_003054759.1	CtsR family transcriptional regulator	-
MP619_RS10865 (MP619_10835)	-	2184859..2185062 (-)	204	WP_003053018.1	cold-shock protein	-
MP619_RS10870 (MP619_10840)	-	2185277..2186299 (-)	1023	WP_129555386.1	IS30 family transposase	-
MP619_RS10875 (MP619_10845)	-	2186389..2186967 (+)	579	WP_232022241.1	hypothetical protein	-
MP619_RS10880 (MP619_10850)	-	2186999..2187157 (-)	159	WP_129556337.1	hypothetical protein	-
MP619_RS10885 (MP619_10855)	-	2187518..2188267 (+)	750	WP_129556338.1	S24 family peptidase	-
MP619_RS10890 (MP619_10860)	-	2188426..2189448 (+)	1023	WP_129555386.1	IS30 family transposase	-
MP619_RS10895 (MP619_10865)	-	2189659..2190603 (+)	945	WP_129556339.1	Abi family protein	-
MP619_RS10900 (MP619_10870)	-	2190725..2191798 (+)	1074	WP_129556340.1	site-specific integrase	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90264.83 Da
• Isoelectric Point: 6.4813

>NTDB_id=675118 MP619_RS10855 WP_129556297.1 2181760..2184204(-) (clpC) [Streptococcus dysgalactiae strain WJ001]
MIMYSLKMQEIFRQAQFQAARFDSQYLETWHILLAMARVDHSLAGLVLSEFDAKVAVEEYEAAAILAMGKSPKDQVSHID
FRPQSKTLTNLLQFAQAISQVTKDQEVGSEHVLFAILLNPDIMATRLLEMAGYTIKDKGNGEPRLADLRKAIEIHAGYSK
EIIKAIHELRKPKKTKNQGSFSDMMKPPSTAGDLADFTRDLTEMASQGLLEPVIGRDAEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIESDGKIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNVEDAYQILLGLKGSYETYHNVTIAD
QAVRTAVKMAHRYLTSKNLPDSAIDLLDEASATVQGMVKKSSPEIITPLDQALIDGDMKKASRLLAKDVKGQHRKPTAVT
EEDILTTLSKLSGIPLEKLSQADSKKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDASALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGMLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKGISHDHQAMEKRILEELKKAYRPEFINRIDEKVVFH
SLTQDNMREVVKIMVQPLMATLAEKGITLKFQPMALKYLSEEGYDVEMGARPLRRTLQTQVEDKLSELILAGELASGHTL
KIGLSHGKLSFNIE

Nucleotide

• Length: 2445 bp

>NTDB_id=675118 MP619_RS10855 WP_129556297.1 2181760..2184204(-) (clpC) [Streptococcus dysgalactiae strain WJ001]
ATGATCATGTATTCATTGAAGATGCAAGAAATTTTCAGGCAAGCGCAGTTTCAAGCAGCCCGCTTTGATAGTCAATACCT
AGAAACTTGGCATATATTGCTAGCTATGGCGAGGGTTGATCACTCCCTAGCGGGCTTGGTGCTAAGCGAATTTGATGCTA
AGGTTGCAGTGGAAGAATATGAGGCTGCAGCTATTTTAGCGATGGGCAAAAGCCCTAAAGACCAAGTGTCTCACATTGAC
TTTAGGCCTCAGTCAAAGACCTTAACGAACCTTTTGCAATTTGCCCAAGCTATCAGTCAAGTCACCAAAGACCAAGAGGT
AGGTTCAGAGCATGTTCTCTTTGCCATTTTGCTTAATCCAGATATTATGGCGACTCGCTTATTAGAGATGGCTGGTTATA
CTATCAAGGATAAAGGAAACGGGGAGCCTCGCTTAGCTGATTTACGAAAAGCTATCGAGATTCATGCAGGCTATAGCAAG
GAAATAATTAAGGCTATCCACGAGTTGCGTAAGCCAAAGAAAACCAAAAATCAAGGTTCTTTTTCAGACATGATGAAGCC
ACCAAGCACGGCTGGGGACTTGGCGGACTTTACACGTGATTTGACCGAGATGGCAAGCCAAGGTCTCTTAGAGCCAGTTA
TTGGGCGTGATGCTGAAGTGTCACGGATGATTCAAGTACTGAGTCGTAAAACCAAGAATAACCCTGTTCTTGTGGGTGAT
GCAGGTGTGGGTAAAACGGCCCTTGCCTACGGCCTTGCTCAACGTATTGCTAATGGTGCTATTCCTTACGAACTGCAAGA
CATGCGTGTTCTAGAGTTAGACATGATGAGTGTTGTTGCGGGAACCCGTTTTCGTGGGGACTTTGAAGAGCGCATGAATC
AAATCATTGACGATATTGAGTCAGATGGCAAGATTATTCTCTTCGTAGATGAATTGCACACCATTATGGGATCAGGAAGT
GGTATTGATAGCACGCTTGATGCTGCCAATATTTTAAAACCAGCCTTATCTCGTGGAACTCTCCATATGGTGGGTGCAAC
AACGCAGGAAGAATACCAAAAACATATTGAAAAAGATGCCGCTCTTTCGCGCCGCTTTGCTAAGATTTTAATTGAAGAAC
CTAATGTAGAAGATGCTTATCAGATTCTGCTAGGACTAAAAGGCTCTTACGAGACTTACCATAATGTGACCATTGCTGAT
CAGGCTGTTAGAACCGCTGTGAAAATGGCACATCGCTATCTGACCAGCAAAAACCTTCCGGATTCTGCCATTGATTTGTT
GGATGAAGCCAGTGCTACAGTGCAAGGTATGGTTAAAAAATCTAGTCCAGAAATCATCACGCCATTAGATCAAGCTTTGA
TTGATGGCGATATGAAGAAAGCCTCTCGTTTGTTGGCAAAAGACGTTAAAGGGCAACATCGCAAGCCAACAGCTGTGACA
GAAGAGGATATCCTGACGACCTTGAGCAAGCTATCAGGTATTCCACTGGAAAAACTCAGCCAAGCTGATAGCAAAAAATA
CCTTAATTTGGAAAAAGAACTGCATAAGCGCGTGATTGGGCAAGAAGATGCTGTCTCAGCTATTTCTAGAGCCATTCGCC
GTAATCAGTCAGGCATTCGTACAGGTAAACGTCCAATCGGTTCTTTCATGTTCCTTGGTCCAACAGGGGTTGGTAAGACC
GAGTTGGCAAAAGCTTTGGCAGAAGTTCTCTTTGATGACGCGTCCGCCCTTATCCGCTTTGATATGTCAGAGTATATGGA
AAAATTTGCGGCTTCTCGCCTTAATGGCGCACCTCCAGGCTATGTCGGTTACGATGAAGGTGGTGAATTAACAGAGAAGG
TCAGAAACAAGCCTTATTCTGTGCTCCTCTTTGACGAGGTGGAAAAAGCTCACCCTGATATTTTCAACGTCCTCTTACAA
GTGCTTGATGATGGCATGTTGACAGATAGCCGTGGGCGTAAAGTGGACTTCTCAAACACCATTATTATCATGACAAGTAA
TCTAGGGGCAACAGCTCTGCGTGATGATAAAACAGTTGGCTTTGGGGCAAAAGGTATCAGCCATGACCACCAAGCCATGG
AAAAACGGATTTTGGAAGAGTTGAAGAAAGCTTACCGACCAGAATTTATCAACCGAATTGATGAAAAGGTTGTCTTCCAC
AGCCTCACTCAGGACAATATGAGAGAAGTGGTCAAGATTATGGTGCAACCGTTGATGGCTACTTTGGCAGAAAAAGGCAT
TACCCTCAAATTCCAGCCAATGGCCCTCAAGTATTTATCAGAAGAAGGGTATGATGTGGAAATGGGTGCTCGTCCATTGC
GCCGCACTTTGCAAACTCAGGTGGAAGATAAATTGTCTGAATTGATTCTTGCTGGTGAATTGGCAAGTGGTCATACCCTG
AAAATTGGCCTTTCTCATGGAAAACTCAGCTTTAACATTGAGTGA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-53)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-137)

• AAA lid domain (AAA_lid_9) (376-462)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	76.753	99.877	0.767
clpC	Streptococcus thermophilus LMG 18311	73.039	100	0.732
clpC	Streptococcus thermophilus LMD-9	73.039	100	0.732
clpC	Streptococcus pneumoniae TIGR4	67.282	99.877	0.672
clpC	Streptococcus pneumoniae Rx1	67.282	99.877	0.672
clpC	Streptococcus pneumoniae D39	67.282	99.877	0.672
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.801	100	0.5
clpC	Bacillus subtilis subsp. subtilis str. 168	42.96	100	0.439