Detailed information NTG0067499

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAFDA_RS09640
• Genome accession: NZ_AP014942
• Coordinates: 1937543..1938586 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDA209P
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1932543..1943586

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAFDA_RS09610 (SAFDA_1767)	-	1932965..1934221 (-)	1257	WP_001793428.1	aminopeptidase	-
SAFDA_RS09615 (SAFDA_1768)	-	1934224..1934424 (-)	201	WP_000180463.1	DUF1128 family protein	-
SAFDA_RS09620 (SAFDA_1769)	-	1934571..1935035 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAFDA_RS09625 (SAFDA_1770)	-	1935042..1935317 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAFDA_RS09630 (SAFDA_1771)	-	1935595..1936812 (+)	1218	WP_042727579.1	YihY/virulence factor BrkB family protein	-
SAFDA_RS09635 (SAFDA_1772)	vraR	1936924..1937553 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAFDA_RS09640 (SAFDA_1773)	vraS	1937543..1938586 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAFDA_RS09645 (SAFDA_1774)	liaF	1938583..1939284 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAFDA_RS09650 (SAFDA_1775)	-	1939299..1939685 (-)	387	WP_001110179.1	hypothetical protein	-
SAFDA_RS09655 (SAFDA_1776)	map	1939902..1940660 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
SAFDA_RS09660 (SAFDA_1777)	-	1941191..1942177 (+)	987	WP_042727578.1	FUSC family protein	-
SAFDA_RS09670 (SAFDA_1778)	-	1942667..1943080 (-)	414	WP_001549145.1	hypothetical protein	-
SAFDA_RS09675	-	1943109..1943219 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=67499 SAFDA_RS09640 WP_001017131.1 1937543..1938586(-) (vraS) [Staphylococcus aureus strain FDA209P]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=67499 SAFDA_RS09640 WP_001017131.1 1937543..1938586(-) (vraS) [Staphylococcus aureus strain FDA209P]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1