Detailed information NTG0674118

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUO45_RS05030
• Genome accession: NZ_CP094926
• Coordinates: 996378..997421 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 14
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 991378..1002421

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUO45_RS05000 (MUO45_04970)	-	991800..993056 (-)	1257	WP_001793428.1	aminopeptidase	-
MUO45_RS05005 (MUO45_04975)	-	993059..993259 (-)	201	WP_000180463.1	DUF1128 family protein	-
MUO45_RS05010 (MUO45_04980)	-	993406..993870 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUO45_RS05015 (MUO45_04985)	-	993877..994152 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUO45_RS05020 (MUO45_04990)	-	994430..995647 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
MUO45_RS05025 (MUO45_04995)	vraR	995759..996388 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUO45_RS05030 (MUO45_05000)	vraS	996378..997421 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUO45_RS05035 (MUO45_05005)	liaF	997418..998119 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUO45_RS05040 (MUO45_05010)	-	998134..998520 (-)	387	WP_001110179.1	hypothetical protein	-
MUO45_RS05045 (MUO45_05015)	map	998737..999495 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
MUO45_RS05050 (MUO45_05020)	-	1000026..1001012 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUO45_RS05055 (MUO45_05025)	-	1001443..1001856 (-)	414	WP_001549145.1	hypothetical protein	-
MUO45_RS05060 (MUO45_05030)	-	1001885..1001995 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=674118 MUO45_RS05030 WP_001017131.1 996378..997421(-) (vraS) [Staphylococcus aureus strain 14]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=674118 MUO45_RS05030 WP_001017131.1 996378..997421(-) (vraS) [Staphylococcus aureus strain 14]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1