Detailed information NTG0674034

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUO49_RS04995
• Genome accession: NZ_CP094924
• Coordinates: 996457..997500 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 18
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 991457..1002500

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUO49_RS04965 (MUO49_04950)	-	991879..993135 (-)	1257	WP_001793428.1	aminopeptidase	-
MUO49_RS04970 (MUO49_04955)	-	993138..993338 (-)	201	WP_000180463.1	DUF1128 family protein	-
MUO49_RS04975 (MUO49_04960)	-	993485..993949 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUO49_RS04980 (MUO49_04965)	-	993956..994231 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUO49_RS04985 (MUO49_04970)	-	994509..995726 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
MUO49_RS04990 (MUO49_04975)	vraR	995838..996467 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUO49_RS04995 (MUO49_04980)	vraS	996457..997500 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUO49_RS05000 (MUO49_04985)	liaF	997497..998198 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUO49_RS05005 (MUO49_04990)	-	998213..998599 (-)	387	WP_001110179.1	hypothetical protein	-
MUO49_RS05010 (MUO49_04995)	map	998816..999574 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
MUO49_RS05015 (MUO49_05000)	-	1000105..1001091 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUO49_RS05020 (MUO49_05005)	-	1001522..1001935 (-)	414	WP_001549145.1	hypothetical protein	-
MUO49_RS05025 (MUO49_05010)	-	1001964..1002074 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=674034 MUO49_RS04995 WP_001017131.1 996457..997500(-) (vraS) [Staphylococcus aureus strain 18]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=674034 MUO49_RS04995 WP_001017131.1 996457..997500(-) (vraS) [Staphylococcus aureus strain 18]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1