Detailed information NTG0673992

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUO47_RS04995
• Genome accession: NZ_CP094923
• Coordinates: 996475..997518 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 1824
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 991475..1002518

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUO47_RS04965 (MUO47_04950)	-	991897..993153 (-)	1257	WP_001793428.1	aminopeptidase	-
MUO47_RS04970 (MUO47_04955)	-	993156..993356 (-)	201	WP_000180463.1	DUF1128 family protein	-
MUO47_RS04975 (MUO47_04960)	-	993503..993967 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUO47_RS04980 (MUO47_04965)	-	993974..994249 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUO47_RS04985 (MUO47_04970)	-	994527..995744 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
MUO47_RS04990 (MUO47_04975)	vraR	995856..996485 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUO47_RS04995 (MUO47_04980)	vraS	996475..997518 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUO47_RS05000 (MUO47_04985)	liaF	997515..998216 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUO47_RS05005 (MUO47_04990)	-	998231..998617 (-)	387	WP_001110179.1	hypothetical protein	-
MUO47_RS05010 (MUO47_04995)	map	998834..999592 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
MUO47_RS05015 (MUO47_05000)	-	1000123..1001109 (+)	987	WP_277445878.1	aromatic acid exporter family protein	-
MUO47_RS05020 (MUO47_05005)	-	1001540..1001953 (-)	414	WP_001549145.1	hypothetical protein	-
MUO47_RS05025 (MUO47_05010)	-	1001982..1002092 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=673992 MUO47_RS04995 WP_001017131.1 996475..997518(-) (vraS) [Staphylococcus aureus strain 1824]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=673992 MUO47_RS04995 WP_001017131.1 996475..997518(-) (vraS) [Staphylococcus aureus strain 1824]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1