Detailed information NTG0673819

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUG62_RS04670
• Genome accession: NZ_CP094872
• Coordinates: 999248..1000294 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain C101
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 994248..1005294

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUG62_RS04645 (MUG62_04645)	-	995389..995925 (+)	537	WP_002470337.1	hypothetical protein	-
MUG62_RS04650 (MUG62_04650)	-	996076..997062 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
MUG62_RS04655 (MUG62_04655)	map	997236..997991 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MUG62_RS04660 (MUG62_04660)	-	998149..998535 (+)	387	WP_001830382.1	hypothetical protein	-
MUG62_RS04665 (MUG62_04665)	liaF	998550..999251 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MUG62_RS04670 (MUG62_04670)	vraS	999248..1000294 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MUG62_RS04675 (MUG62_04675)	vraR	1000284..1000913 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MUG62_RS04680 (MUG62_04680)	-	1000970..1002148 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MUG62_RS04685 (MUG62_04685)	-	1002555..1002839 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MUG62_RS04690 (MUG62_04690)	-	1002847..1003311 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MUG62_RS04695 (MUG62_04695)	-	1003452..1003667 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MUG62_RS04700 (MUG62_04700)	-	1003669..1004910 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=673819 MUG62_RS04670 WP_001830374.1 999248..1000294(+) (vraS) [Staphylococcus epidermidis strain C101]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=673819 MUG62_RS04670 WP_001830374.1 999248..1000294(+) (vraS) [Staphylococcus epidermidis strain C101]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92