Detailed information NTG0673694

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MTX64_RS10175
• Genome accession: NZ_CP094855
• Coordinates: 2045273..2046316 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017127.1
• Uniprot ID: A0A1L6C0A3
• Organism: Staphylococcus aureus strain NY2491
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2040273..2051316

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MTX64_RS10145 (MTX64_10145)	-	2040691..2041947 (-)	1257	WP_001795438.1	aminopeptidase	-
MTX64_RS10150 (MTX64_10150)	-	2041950..2042150 (-)	201	WP_000180461.1	DUF1128 family protein	-
MTX64_RS10155 (MTX64_10155)	-	2042297..2042761 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MTX64_RS10160 (MTX64_10160)	-	2042768..2043043 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MTX64_RS10165 (MTX64_10165)	-	2043321..2044538 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
MTX64_RS10170 (MTX64_10170)	vraR	2044654..2045283 (-)	630	WP_000153525.1	two-component system response regulator VraR	Regulator
MTX64_RS10175 (MTX64_10175)	vraS	2045273..2046316 (-)	1044	WP_001017127.1	sensor histidine kinase	Regulator
MTX64_RS10180 (MTX64_10180)	liaF	2046313..2047014 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MTX64_RS10185 (MTX64_10185)	-	2047029..2047415 (-)	387	WP_001110179.1	hypothetical protein	-
MTX64_RS10190 (MTX64_10190)	map	2047632..2048390 (-)	759	WP_000636146.1	type I methionyl aminopeptidase	-
MTX64_RS10195 (MTX64_10195)	-	2048918..2049904 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MTX64_RS10200 (MTX64_10200)	-	2050335..2050748 (-)	414	WP_001549145.1	hypothetical protein	-
MTX64_RS10205 (MTX64_10205)	-	2050777..2050887 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40002.44 Da
• Isoelectric Point: 6.0577

>NTDB_id=673694 MTX64_RS10175 WP_001017127.1 2045273..2046316(-) (vraS) [Staphylococcus aureus strain NY2491]
MNHYIRTIGSMLILGYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=673694 MTX64_RS10175 WP_001017127.1 2045273..2046316(-) (vraS) [Staphylococcus aureus strain NY2491]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGGATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A1L6C0A3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997