Detailed information NTG0673651

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MTX62_RS09860
• Genome accession: NZ_CP094853
• Coordinates: 2000733..2001776 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017127.1
• Uniprot ID: A0A1L6C0A3
• Organism: Staphylococcus aureus strain NY2010
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1995733..2006776

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MTX62_RS09830 (MTX62_09830)	-	1996151..1997407 (-)	1257	WP_001795438.1	aminopeptidase	-
MTX62_RS09835 (MTX62_09835)	-	1997410..1997610 (-)	201	WP_000180461.1	DUF1128 family protein	-
MTX62_RS09840 (MTX62_09840)	-	1997757..1998221 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MTX62_RS09845 (MTX62_09845)	-	1998228..1998503 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MTX62_RS09850 (MTX62_09850)	-	1998781..1999998 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
MTX62_RS09855 (MTX62_09855)	vraR	2000114..2000743 (-)	630	WP_000153525.1	two-component system response regulator VraR	Regulator
MTX62_RS09860 (MTX62_09860)	vraS	2000733..2001776 (-)	1044	WP_001017127.1	sensor histidine kinase	Regulator
MTX62_RS09865 (MTX62_09865)	liaF	2001773..2002474 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MTX62_RS09870 (MTX62_09870)	-	2002489..2002875 (-)	387	WP_001110179.1	hypothetical protein	-
MTX62_RS09875 (MTX62_09875)	map	2003092..2003850 (-)	759	WP_000636146.1	type I methionyl aminopeptidase	-
MTX62_RS09880 (MTX62_09880)	-	2004378..2005364 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MTX62_RS09885 (MTX62_09885)	-	2005795..2006208 (-)	414	WP_001549145.1	hypothetical protein	-
MTX62_RS09890 (MTX62_09890)	-	2006237..2006347 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40002.44 Da
• Isoelectric Point: 6.0577

>NTDB_id=673651 MTX62_RS09860 WP_001017127.1 2000733..2001776(-) (vraS) [Staphylococcus aureus strain NY2010]
MNHYIRTIGSMLILGYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=673651 MTX62_RS09860 WP_001017127.1 2000733..2001776(-) (vraS) [Staphylococcus aureus strain NY2010]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGGATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A1L6C0A3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997