Detailed information NTG0672895

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA25_RS10380
• Genome accession: NZ_CP094801
• Coordinates: 2059050..2060093 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6155
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2054050..2065093

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA25_RS10350 (MUA25_10345)	-	2054471..2055727 (-)	1257	WP_001793983.1	aminopeptidase	-
MUA25_RS10355 (MUA25_10350)	-	2055730..2055930 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA25_RS10360 (MUA25_10355)	-	2056077..2056541 (+)	465	WP_252592522.1	low molecular weight protein-tyrosine-phosphatase	-
MUA25_RS10365 (MUA25_10360)	-	2056548..2056823 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA25_RS10370 (MUA25_10365)	-	2057101..2058318 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA25_RS10375 (MUA25_10370)	vraR	2058431..2059060 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA25_RS10380 (MUA25_10375)	vraS	2059050..2060093 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA25_RS10385 (MUA25_10380)	liaF	2060090..2060791 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA25_RS10390 (MUA25_10385)	-	2060806..2061192 (-)	387	WP_001110178.1	hypothetical protein	-
MUA25_RS10395 (MUA25_10390)	map	2061409..2062167 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA25_RS10400 (MUA25_10395)	-	2062923..2063909 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA25_RS10405 (MUA25_10400)	-	2064098..2064511 (-)	414	WP_001643743.1	hypothetical protein	-
MUA25_RS10410 (MUA25_10405)	-	2064540..2064650 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672895 MUA25_RS10380 WP_001017131.1 2059050..2060093(-) (vraS) [Staphylococcus aureus strain IVB6155]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672895 MUA25_RS10380 WP_001017131.1 2059050..2060093(-) (vraS) [Staphylococcus aureus strain IVB6155]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1