Detailed information NTG0672772

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA16_RS09825
• Genome accession: NZ_CP094797
• Coordinates: 1984262..1985305 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6163
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1979262..1990305

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA16_RS09795 (MUA16_09785)	-	1979683..1980939 (-)	1257	WP_001793983.1	aminopeptidase	-
MUA16_RS09800 (MUA16_09790)	-	1980942..1981142 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA16_RS09805 (MUA16_09795)	-	1981289..1981753 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA16_RS09810 (MUA16_09800)	-	1981760..1982035 (+)	276	WP_069631803.1	hypothetical protein	-
MUA16_RS09815 (MUA16_09805)	-	1982313..1983530 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA16_RS09820 (MUA16_09810)	vraR	1983643..1984272 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA16_RS09825 (MUA16_09815)	vraS	1984262..1985305 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA16_RS09830 (MUA16_09820)	liaF	1985302..1986003 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA16_RS09835 (MUA16_09825)	-	1986018..1986404 (-)	387	WP_001110178.1	hypothetical protein	-
MUA16_RS09840 (MUA16_09830)	map	1986621..1987379 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA16_RS09845 (MUA16_09835)	-	1988135..1989121 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA16_RS09850 (MUA16_09840)	-	1989310..1989723 (-)	414	WP_001643743.1	hypothetical protein	-
MUA16_RS09855 (MUA16_09845)	-	1989752..1989862 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672772 MUA16_RS09825 WP_001017131.1 1984262..1985305(-) (vraS) [Staphylococcus aureus strain IVB6163]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672772 MUA16_RS09825 WP_001017131.1 1984262..1985305(-) (vraS) [Staphylococcus aureus strain IVB6163]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1