Detailed information NTG0672731

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA75_RS09575
• Genome accession: NZ_CP094795
• Coordinates: 1958065..1959108 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6164
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1953065..1964108

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA75_RS09545 (MUA75_09535)	-	1953486..1954742 (-)	1257	WP_001793428.1	aminopeptidase	-
MUA75_RS09550 (MUA75_09540)	-	1954745..1954945 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA75_RS09555 (MUA75_09545)	-	1955092..1955556 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA75_RS09560 (MUA75_09550)	-	1955563..1955838 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA75_RS09565 (MUA75_09555)	-	1956116..1957333 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
MUA75_RS09570 (MUA75_09560)	vraR	1957446..1958075 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA75_RS09575 (MUA75_09565)	vraS	1958065..1959108 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA75_RS09580 (MUA75_09570)	liaF	1959105..1959806 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
MUA75_RS09585 (MUA75_09575)	-	1959821..1960207 (-)	387	WP_001110179.1	hypothetical protein	-
MUA75_RS09590 (MUA75_09580)	map	1960424..1961182 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA75_RS09595 (MUA75_09585)	-	1961709..1962695 (+)	987	WP_000999713.1	FUSC family protein	-
MUA75_RS09600 (MUA75_09590)	-	1962884..1963297 (-)	414	WP_252550078.1	hypothetical protein	-
MUA75_RS09605 (MUA75_09595)	-	1963326..1963438 (-)	113	Protein_1855	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672731 MUA75_RS09575 WP_001017131.1 1958065..1959108(-) (vraS) [Staphylococcus aureus strain IVB6164]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672731 MUA75_RS09575 WP_001017131.1 1958065..1959108(-) (vraS) [Staphylococcus aureus strain IVB6164]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1