Detailed information NTG0672606

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA09_RS10730
• Genome accession: NZ_CP094789
• Coordinates: 2115023..2116066 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6167
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2110023..2121066

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA09_RS10700 (MUA09_10680)	-	2110444..2111700 (-)	1257	WP_078103544.1	aminopeptidase	-
MUA09_RS10705 (MUA09_10685)	-	2111703..2111903 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA09_RS10710 (MUA09_10690)	-	2112050..2112514 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA09_RS10715 (MUA09_10695)	-	2112521..2112796 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA09_RS10720 (MUA09_10700)	-	2113074..2114291 (+)	1218	WP_045179336.1	YihY/virulence factor BrkB family protein	-
MUA09_RS10725 (MUA09_10705)	vraR	2114404..2115033 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA09_RS10730 (MUA09_10710)	vraS	2115023..2116066 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA09_RS10735 (MUA09_10715)	liaF	2116063..2116764 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA09_RS10740 (MUA09_10720)	-	2116779..2117165 (-)	387	WP_001110178.1	hypothetical protein	-
MUA09_RS10745 (MUA09_10725)	map	2117382..2118140 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA09_RS10750 (MUA09_10730)	-	2118896..2119882 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA09_RS10755 (MUA09_10735)	-	2120071..2120484 (-)	414	WP_001643743.1	hypothetical protein	-
MUA09_RS10760 (MUA09_10740)	-	2120513..2120623 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672606 MUA09_RS10730 WP_001017131.1 2115023..2116066(-) (vraS) [Staphylococcus aureus strain IVB6167]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672606 MUA09_RS10730 WP_001017131.1 2115023..2116066(-) (vraS) [Staphylococcus aureus strain IVB6167]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1