Detailed information NTG0672308

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA47_RS09945
• Genome accession: NZ_CP094773
• Coordinates: 2015344..2016387 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6195
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2010344..2021387

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA47_RS09915 (MUA47_09915)	-	2010763..2012019 (-)	1257	WP_250425878.1	aminopeptidase	-
MUA47_RS09920 (MUA47_09920)	-	2012022..2012222 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA47_RS09925 (MUA47_09925)	-	2012369..2012833 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA47_RS09930 (MUA47_09930)	-	2012840..2013115 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA47_RS09935 (MUA47_09935)	-	2013395..2014612 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA47_RS09940 (MUA47_09940)	vraR	2014725..2015354 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA47_RS09945 (MUA47_09945)	vraS	2015344..2016387 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA47_RS09950 (MUA47_09950)	liaF	2016384..2017085 (-)	702	WP_262634652.1	cell wall-active antibiotics response protein LiaF	-
MUA47_RS09955 (MUA47_09955)	-	2017100..2017486 (-)	387	WP_001110179.1	hypothetical protein	-
MUA47_RS09960 (MUA47_09960)	map	2017703..2018461 (-)	759	WP_111014375.1	type I methionyl aminopeptidase	-
MUA47_RS09965 (MUA47_09965)	-	2019047..2020033 (+)	987	WP_262634653.1	FUSC family protein	-
MUA47_RS09970 (MUA47_09970)	-	2020221..2020634 (-)	414	WP_025174666.1	hypothetical protein	-
MUA47_RS09975 (MUA47_09975)	-	2020663..2020773 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672308 MUA47_RS09945 WP_001017131.1 2015344..2016387(-) (vraS) [Staphylococcus aureus strain IVB6195]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672308 MUA47_RS09945 WP_001017131.1 2015344..2016387(-) (vraS) [Staphylococcus aureus strain IVB6195]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1