Detailed information NTG0672014

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA32_RS09975
• Genome accession: NZ_CP094755
• Coordinates: 2003992..2005035 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6242
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1998992..2010035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA32_RS09945 (MUA32_09935)	-	1999413..2000669 (-)	1257	WP_001793983.1	aminopeptidase	-
MUA32_RS09950 (MUA32_09940)	-	2000672..2000872 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA32_RS09955 (MUA32_09945)	-	2001019..2001483 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA32_RS09960 (MUA32_09950)	-	2001490..2001765 (+)	276	WP_069631803.1	hypothetical protein	-
MUA32_RS09965 (MUA32_09955)	-	2002043..2003260 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA32_RS09970 (MUA32_09960)	vraR	2003373..2004002 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA32_RS09975 (MUA32_09965)	vraS	2003992..2005035 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA32_RS09980 (MUA32_09970)	liaF	2005032..2005733 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA32_RS09985 (MUA32_09975)	-	2005748..2006134 (-)	387	WP_001110178.1	hypothetical protein	-
MUA32_RS09990 (MUA32_09980)	map	2006351..2007109 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA32_RS09995 (MUA32_09985)	-	2007865..2008851 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA32_RS10000 (MUA32_09990)	-	2009040..2009453 (-)	414	WP_001643743.1	hypothetical protein	-
MUA32_RS10005 (MUA32_09995)	-	2009482..2009592 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672014 MUA32_RS09975 WP_001017131.1 2003992..2005035(-) (vraS) [Staphylococcus aureus strain IVB6242]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672014 MUA32_RS09975 WP_001017131.1 2003992..2005035(-) (vraS) [Staphylococcus aureus strain IVB6242]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1