Detailed information NTG0671930

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA07_RS09800
• Genome accession: NZ_CP094750
• Coordinates: 1998355..1999398 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6248
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1993355..2004398

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA07_RS09770 (MUA07_09770)	-	1993776..1995032 (-)	1257	WP_262541882.1	aminopeptidase	-
MUA07_RS09775 (MUA07_09775)	-	1995035..1995235 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA07_RS09780 (MUA07_09780)	-	1995382..1995846 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA07_RS09785 (MUA07_09785)	-	1995853..1996128 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA07_RS09790 (MUA07_09790)	-	1996406..1997623 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
MUA07_RS09795 (MUA07_09795)	vraR	1997736..1998365 (-)	630	WP_262541884.1	two-component system response regulator VraR	Regulator
MUA07_RS09800 (MUA07_09800)	vraS	1998355..1999398 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA07_RS09805 (MUA07_09805)	liaF	1999395..2000096 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
MUA07_RS09810 (MUA07_09810)	-	2000111..2000497 (-)	387	WP_001110179.1	hypothetical protein	-
MUA07_RS09815 (MUA07_09815)	map	2000714..2001472 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA07_RS09820 (MUA07_09820)	-	2001999..2002985 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUA07_RS09825 (MUA07_09825)	-	2003174..2003587 (-)	414	WP_262542369.1	hypothetical protein	-
MUA07_RS09830 (MUA07_09830)	-	2003616..2003728 (-)	113	Protein_1899	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=671930 MUA07_RS09800 WP_001017131.1 1998355..1999398(-) (vraS) [Staphylococcus aureus strain IVB6248]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=671930 MUA07_RS09800 WP_001017131.1 1998355..1999398(-) (vraS) [Staphylococcus aureus strain IVB6248]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1