Detailed information NTG0671849

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA64_RS10175
• Genome accession: NZ_CP094745
• Coordinates: 2036043..2037086 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6250
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2031043..2042086

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA64_RS10145 (MUA64_10145)	-	2031464..2032720 (-)	1257	WP_001793983.1	aminopeptidase	-
MUA64_RS10150 (MUA64_10150)	-	2032723..2032923 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA64_RS10155 (MUA64_10155)	-	2033070..2033534 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA64_RS10160 (MUA64_10160)	-	2033541..2033816 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA64_RS10165 (MUA64_10165)	-	2034094..2035311 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA64_RS10170 (MUA64_10170)	vraR	2035424..2036053 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA64_RS10175 (MUA64_10175)	vraS	2036043..2037086 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA64_RS10180 (MUA64_10180)	liaF	2037083..2037784 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA64_RS10185 (MUA64_10185)	-	2037799..2038185 (-)	387	WP_001110178.1	hypothetical protein	-
MUA64_RS10190 (MUA64_10190)	map	2038402..2039160 (-)	759	WP_252559258.1	type I methionyl aminopeptidase	-
MUA64_RS10195 (MUA64_10195)	-	2039916..2040902 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA64_RS10200 (MUA64_10200)	-	2041091..2041504 (-)	414	WP_001643743.1	hypothetical protein	-
MUA64_RS10205 (MUA64_10205)	-	2041533..2041643 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=671849 MUA64_RS10175 WP_001017131.1 2036043..2037086(-) (vraS) [Staphylococcus aureus strain IVB6250]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=671849 MUA64_RS10175 WP_001017131.1 2036043..2037086(-) (vraS) [Staphylococcus aureus strain IVB6250]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1