Detailed information NTG0670930

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA46_RS04305
• Genome accession: NZ_CP094711
• Coordinates: 954166..955209 (+)
• Length: 347 a.a.
• NCBI ID: WP_050330549.1
• Uniprot ID: A0A0K1ACB9
• Organism: Staphylococcus schleiferi strain IVB6184
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 949166..960209

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA46_RS04280 (MUA46_04270)	-	949588..950727 (+)	1140	WP_242678349.1	exo-alpha-sialidase	-
MUA46_RS04285 (MUA46_04275)	-	951111..952109 (-)	999	WP_194368683.1	aromatic acid exporter family protein	-
MUA46_RS04290 (MUA46_04280)	map	952207..952968 (+)	762	WP_167732697.1	type I methionyl aminopeptidase	-
MUA46_RS04295 (MUA46_04285)	-	953066..953455 (+)	390	WP_016425509.1	hypothetical protein	-
MUA46_RS04300 (MUA46_04290)	liaF	953468..954169 (+)	702	WP_016425508.1	cell wall-active antibiotics response protein LiaF	-
MUA46_RS04305 (MUA46_04295)	vraS	954166..955209 (+)	1044	WP_050330549.1	sensor histidine kinase	Regulator
MUA46_RS04310 (MUA46_04300)	vraR	955199..955828 (+)	630	WP_016425506.1	response regulator transcription factor	Regulator
MUA46_RS04315 (MUA46_04305)	-	955883..956455 (-)	573	WP_016425505.1	carbonic anhydrase	-
MUA46_RS04320 (MUA46_04310)	-	956488..957747 (-)	1260	WP_016425504.1	YihY/virulence factor BrkB family protein	-
MUA46_RS04325 (MUA46_04315)	-	958038..958325 (-)	288	WP_016425503.1	YtxH domain-containing protein	-
MUA46_RS04330 (MUA46_04320)	-	958333..958791 (-)	459	WP_016425502.1	low molecular weight protein-tyrosine-phosphatase	-
MUA46_RS04335 (MUA46_04325)	-	958924..959127 (+)	204	WP_016425501.1	DUF1128 family protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40139.47 Da
• Isoelectric Point: 5.4523

>NTDB_id=670930 MUA46_RS04305 WP_050330549.1 954166..955209(+) (vraS) [Staphylococcus schleiferi strain IVB6184]
MNHYVRAIGSMLILVYSMFTAFFFIDKVFTNIIYFQGMFYTQIFGIPVFIFLNLIVIFLCIIVGSVLAYKINQQNDWLKQ
QIERAFEGETVGINDQHIELYNETIELYQALVPLNQELHKMRIKTQNLTNESYNMNDLKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDRSLGEGIKSLVTDLQRKVPMKVVQEI
DEFEVPKGIEDHLFRITQEAISNTLRHAKGKQVTVELLNREDYLLLRIQDDGIGFNVDDKLEQSYGLKNMRERAIEIGAT
FHIVSLPDAGTRIEVKAPLDKEVHNDN

Nucleotide

• Length: 1044 bp

>NTDB_id=670930 MUA46_RS04305 WP_050330549.1 954166..955209(+) (vraS) [Staphylococcus schleiferi strain IVB6184]
ATGAACCATTACGTTCGTGCCATAGGCTCAATGTTGATTTTAGTCTACAGTATGTTTACTGCTTTTTTCTTTATTGATAA
AGTCTTTACTAATATCATTTATTTTCAAGGCATGTTTTATACCCAGATTTTTGGGATTCCCGTATTTATCTTTTTAAATT
TAATCGTTATCTTTCTTTGTATCATTGTAGGTAGCGTACTTGCCTATAAAATCAATCAACAAAATGATTGGTTGAAGCAA
CAAATTGAACGTGCATTTGAAGGGGAAACAGTAGGGATCAATGACCAACATATCGAATTATATAATGAGACGATTGAACT
GTATCAAGCCCTTGTTCCTTTGAATCAAGAACTTCATAAAATGCGTATTAAAACTCAAAATTTAACGAACGAATCTTATA
ATATGAACGATTTGAAAGTGAAAAAAATAATTGAAGATGAGAGACAACGGTTGGCTAGGGAATTACACGATAGTGTGTCC
CAACAACTCTTTGCGGCAAGCATGATGTTATCCGCGATTAAAGAAACAGAGTTAACCCCACCACTCGATCAGCAAATTCC
AACTTTAGAGAAAATGGTCCAAGATTCTCAGTTGGAGATGCGGGCGTTATTGTTACATTTGAGACCGATAGGACTTAAAG
ACCGCTCGTTAGGTGAAGGTATTAAATCATTAGTTACAGATCTACAAAGAAAAGTTCCAATGAAAGTTGTACAAGAAATT
GACGAATTTGAAGTGCCAAAAGGGATAGAAGACCACTTATTTCGAATCACTCAAGAAGCCATCTCTAATACATTACGTCA
TGCTAAAGGGAAACAAGTTACTGTCGAATTGCTCAATCGTGAAGACTATTTATTGTTGCGTATTCAAGATGACGGTATCG
GTTTTAATGTAGATGACAAATTAGAGCAAAGTTATGGACTTAAAAATATGCGTGAACGTGCAATAGAAATCGGGGCAACC
TTTCATATCGTTTCATTGCCAGACGCTGGGACGAGAATAGAAGTAAAGGCACCACTTGATAAGGAGGTACATAATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A0K1ACB9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	84.438	100	0.844