Detailed information NTG0669513

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: MTP23_RS10405
• Genome accession: NZ_CP094443
• Coordinates: 2077030..2078379 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain N10CSA27
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2077030..2098395	2077030..2078379	within	0

Gene organization within MGE regions

Location: 2077030..2098395

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MTP23_RS10405 (MTP23_10405)	ccrA	2077030..2078379 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
MTP23_RS10410 (MTP23_10410)	ccrB	2078401..2080029 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
MTP23_RS10415 (MTP23_10415)	-	2080547..2080897 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
MTP23_RS10420 (MTP23_10420)	-	2080984..2081295 (+)	312	WP_000700853.1	DUF960 family protein	-
MTP23_RS10425 (MTP23_10425)	-	2081313..2081819 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
MTP23_RS10430 (MTP23_10430)	-	2081840..2082157 (+)	318	WP_000659050.1	JAB domain-containing protein	-
MTP23_RS10435 (MTP23_10435)	-	2082276..2083361 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
MTP23_RS10440 (MTP23_10440)	-	2083358..2085250 (+)	1893	WP_001557544.1	site-specific integrase	-
MTP23_RS10445 (MTP23_10445)	-	2085257..2085634 (+)	378	WP_000361059.1	DUF6262 family protein	-
MTP23_RS10450 (MTP23_10450)	-	2085785..2086567 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
MTP23_RS10455 (MTP23_10455)	erm(A)	2086693..2087424 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
MTP23_RS10460 (MTP23_10460)	-	2087958..2088620 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
MTP23_RS10470 (MTP23_10470)	-	2088965..2089603 (-)	639	Protein_2036	sulfite exporter TauE/SafE family protein	-
MTP23_RS10475 (MTP23_10475)	cstR	2089603..2089863 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
MTP23_RS10480 (MTP23_10480)	-	2089999..2091063 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
MTP23_RS10485 (MTP23_10485)	cstB	2091096..2092430 (+)	1335	Protein_2039	persulfide dioxygenase-sulfurtransferase CstB	-
MTP23_RS10490 (MTP23_10490)	-	2092544..2093653 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
MTP23_RS10495 (MTP23_10495)	psm-mec	2094008..2094076 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
MTP23_RS10500 (MTP23_10500)	mecI	2094161..2094532 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
MTP23_RS10505 (MTP23_10505)	mecR1	2094532..2096289 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
MTP23_RS10510 (MTP23_10510)	mecA	2096386..2098395 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=669513 MTP23_RS10405 WP_000815646.1 2077030..2078379(+) (ccrA) [Staphylococcus aureus strain N10CSA27]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=669513 MTP23_RS10405 WP_000815646.1 2077030..2078379(+) (ccrA) [Staphylococcus aureus strain N10CSA27]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748