Detailed information
Bioinformatically predicted
Overview
| Name | uvrC | Type | Machinery gene |
| Locus tag | MPG49_RS04670 | Genome accession | NZ_CP094173 |
| Coordinates | 978103..979887 (+) | Length | 594 a.a. |
| NCBI ID | WP_245051790.1 | Uniprot ID | - |
| Organism | Helicobacter pylori strain Hpfe0001 | ||
| Function | integration of short DNA fragment (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 976817..1053656 | 978103..979887 | within | 0 |
Gene organization within MGE regions
Location: 976817..1053656
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPG49_RS04655 (MPG49_04655) | - | 976817..977458 (+) | 642 | WP_245051788.1 | ABC transporter ATP-binding protein | - |
| MPG49_RS04660 (MPG49_04660) | - | 977470..977649 (-) | 180 | WP_000468796.1 | hypothetical protein | - |
| MPG49_RS04665 (MPG49_04665) | - | 977641..978102 (+) | 462 | WP_000437184.1 | hypothetical protein | - |
| MPG49_RS04670 (MPG49_04670) | uvrC | 978103..979887 (+) | 1785 | WP_245051790.1 | excinuclease ABC subunit UvrC | Machinery gene |
| MPG49_RS04675 (MPG49_04675) | - | 979898..981163 (+) | 1266 | WP_245051792.1 | homoserine dehydrogenase | - |
| MPG49_RS04680 (MPG49_04680) | - | 981164..981508 (+) | 345 | WP_245051794.1 | YraN family protein | - |
| MPG49_RS04685 (MPG49_04685) | trxA | 981597..981917 (+) | 321 | WP_245051796.1 | thioredoxin | - |
| MPG49_RS04690 (MPG49_04690) | trxB | 981923..982858 (+) | 936 | WP_024773194.1 | thioredoxin-disulfide reductase | - |
| MPG49_RS04695 (MPG49_04695) | - | 983025..983846 (+) | 822 | WP_245051798.1 | glycosyltransferase family 25 protein | - |
| MPG49_RS04700 (MPG49_04700) | - | 984044..984292 (-) | 249 | WP_120945577.1 | RNA-binding protein | - |
| MPG49_RS04705 (MPG49_04705) | - | 984611..985291 (-) | 681 | WP_000401225.1 | F0F1 ATP synthase subunit A | - |
| MPG49_RS04710 (MPG49_04710) | guaB | 985413..986858 (-) | 1446 | WP_245051800.1 | IMP dehydrogenase | - |
| MPG49_RS04715 (MPG49_04715) | gatA | 986868..988229 (-) | 1362 | WP_245051801.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| MPG49_RS04720 (MPG49_04720) | coaE | 988288..988878 (-) | 591 | WP_245051802.1 | dephospho-CoA kinase | - |
| MPG49_RS04725 (MPG49_04725) | - | 988880..989668 (-) | 789 | WP_000265065.1 | spermidine synthase | - |
| MPG49_RS04730 (MPG49_04730) | - | 989758..990645 (-) | 888 | WP_245051803.1 | hypothetical protein | - |
| MPG49_RS04735 (MPG49_04735) | der | 990722..992107 (+) | 1386 | WP_245051804.1 | ribosome biogenesis GTPase Der | - |
| MPG49_RS04740 (MPG49_04740) | - | 992250..992534 (+) | 285 | WP_001029095.1 | HU family DNA-binding protein | - |
| MPG49_RS04750 (MPG49_04750) | - | 993207..993812 (+) | 606 | WP_001236613.1 | LPP20 family lipoprotein | - |
| MPG49_RS04755 (MPG49_04755) | - | 993831..994448 (+) | 618 | WP_140601475.1 | hypothetical protein | - |
| MPG49_RS04760 (MPG49_04760) | - | 994445..996208 (+) | 1764 | WP_245051805.1 | OmpP1/FadL family transporter | - |
| MPG49_RS04765 (MPG49_04765) | pseB | 996223..997206 (+) | 984 | WP_096412506.1 | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | - |
| MPG49_RS04770 (MPG49_04770) | coaBC | 997203..998480 (+) | 1278 | WP_245051806.1 | bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC | - |
| MPG49_RS04775 (MPG49_04775) | - | 998480..999217 (+) | 738 | WP_245051807.1 | hypothetical protein | - |
| MPG49_RS04780 (MPG49_04780) | thiE | 999242..999901 (-) | 660 | WP_245051808.1 | thiamine phosphate synthase | - |
| MPG49_RS04785 (MPG49_04785) | thiD | 999894..1000703 (-) | 810 | WP_245051809.1 | bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase | - |
| MPG49_RS04790 (MPG49_04790) | thiM | 1000700..1001479 (-) | 780 | WP_245051810.1 | hydroxyethylthiazole kinase | - |
| MPG49_RS04795 (MPG49_04795) | - | 1001572..1004568 (-) | 2997 | WP_245051811.1 | type I restriction endonuclease subunit R | - |
| MPG49_RS04800 (MPG49_04800) | - | 1004650..1005858 (-) | 1209 | WP_245051763.1 | restriction endonuclease subunit S | - |
| MPG49_RS04805 (MPG49_04805) | - | 1005851..1007440 (-) | 1590 | WP_245051812.1 | type I restriction-modification system subunit M | - |
| MPG49_RS04810 (MPG49_04810) | - | 1007620..1008306 (+) | 687 | WP_245051813.1 | phosphatase PAP2 family protein | - |
| MPG49_RS04815 (MPG49_04815) | - | 1008333..1009259 (-) | 927 | WP_245051814.1 | COG2958 family protein | - |
| MPG49_RS04820 (MPG49_04820) | - | 1009256..1010857 (-) | 1602 | WP_245051815.1 | ATP-binding cassette domain-containing protein | - |
| MPG49_RS04825 (MPG49_04825) | guaC | 1011106..1012083 (+) | 978 | WP_245051816.1 | GMP reductase | - |
| MPG49_RS04830 (MPG49_04830) | gmhA | 1012251..1012829 (-) | 579 | WP_245051817.1 | D-sedoheptulose 7-phosphate isomerase | - |
| MPG49_RS04835 (MPG49_04835) | rfaE1 | 1012822..1014207 (-) | 1386 | WP_245051818.1 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | - |
| MPG49_RS04840 (MPG49_04840) | rfaD | 1014204..1015196 (-) | 993 | WP_245051819.1 | ADP-glyceromanno-heptose 6-epimerase | - |
| MPG49_RS04845 (MPG49_04845) | gmhB | 1015205..1015729 (-) | 525 | WP_029568139.1 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | - |
| MPG49_RS04850 (MPG49_04850) | - | 1015716..1016453 (-) | 738 | WP_245051820.1 | sulfite exporter TauE/SafE family protein | - |
| MPG49_RS04855 (MPG49_04855) | - | 1016444..1017109 (-) | 666 | WP_245051821.1 | type III pantothenate kinase | - |
| MPG49_RS04860 (MPG49_04860) | - | 1017114..1018784 (-) | 1671 | WP_245051822.1 | plasminogen-binding protein pgbA C-terminal domain-containing protein | - |
| MPG49_RS04865 (MPG49_04865) | - | 1018789..1019445 (-) | 657 | WP_000022988.1 | hypothetical protein | - |
| MPG49_RS04870 (MPG49_04870) | dut | 1019442..1019879 (-) | 438 | WP_000694164.1 | dUTP diphosphatase | - |
| MPG49_RS04875 (MPG49_04875) | greA | 1019869..1020363 (-) | 495 | WP_001031321.1 | transcription elongation factor GreA | - |
| MPG49_RS04880 (MPG49_04880) | lpxB | 1020404..1021486 (-) | 1083 | WP_245051823.1 | lipid-A-disaccharide synthase | - |
| MPG49_RS04885 (MPG49_04885) | mua | 1021486..1021947 (-) | 462 | WP_245051824.1 | nickel-binding protein Mua | - |
| MPG49_RS04890 (MPG49_04890) | hypA | 1021951..1022304 (-) | 354 | WP_000545282.1 | hydrogenase/urease nickel incorporation protein HypA | - |
| MPG49_RS04895 (MPG49_04895) | flgE | 1022363..1024519 (-) | 2157 | WP_050836395.1 | flagellar hook protein FlgE | - |
| MPG49_RS04900 (MPG49_04900) | cdh | 1024721..1025604 (-) | 884 | Protein_948 | CDP-diacylglycerol diphosphatase | - |
| MPG49_RS04905 (MPG49_04905) | - | 1025777..1026106 (+) | 330 | WP_245051826.1 | zinc ribbon domain-containing protein YjdM | - |
| MPG49_RS04910 (MPG49_04910) | - | 1026164..1026379 (-) | 216 | WP_001206520.1 | hypothetical protein | - |
| MPG49_RS04915 (MPG49_04915) | - | 1026460..1027335 (-) | 876 | WP_231254578.1 | twin-arginine translocation signal domain-containing protein | - |
| MPG49_RS04920 (MPG49_04920) | - | 1027486..1029003 (-) | 1518 | WP_017282104.1 | catalase | - |
| MPG49_RS04925 (MPG49_04925) | - | 1029324..1031699 (+) | 2376 | WP_245051827.1 | TonB-dependent receptor | - |
| MPG49_RS04930 (MPG49_04930) | ruvC | 1031700..1032173 (-) | 474 | WP_001221170.1 | crossover junction endodeoxyribonuclease RuvC | - |
| MPG49_RS04935 (MPG49_04935) | - | 1032304..1033029 (+) | 726 | WP_000646751.1 | NYN domain-containing protein | - |
| MPG49_RS04940 (MPG49_04940) | - | 1033581..1034027 (-) | 447 | Protein_956 | hypothetical protein | - |
| MPG49_RS04945 (MPG49_04945) | - | 1034009..1034362 (-) | 354 | WP_245051828.1 | hypothetical protein | - |
| MPG49_RS04950 (MPG49_04950) | - | 1034364..1036691 (-) | 2328 | WP_342376528.1 | DUF3519 domain-containing protein | - |
| MPG49_RS04955 (MPG49_04955) | - | 1037108..1037773 (-) | 666 | WP_342376981.1 | DUF3519 domain-containing protein | - |
| MPG49_RS04960 (MPG49_04960) | hofD | 1037881..1039278 (-) | 1398 | WP_245051829.1 | outer membrane beta-barrel protein HofD | - |
| MPG49_RS04965 (MPG49_04965) | hofC | 1039350..1040936 (-) | 1587 | WP_140537060.1 | outer membrane beta-barrel protein HofC | - |
| MPG49_RS04970 (MPG49_04970) | - | 1041218..1042162 (+) | 945 | WP_245051830.1 | catalase | - |
| MPG49_RS04975 (MPG49_04975) | - | 1042398..1043151 (-) | 754 | Protein_963 | restriction endonuclease | - |
| MPG49_RS04980 (MPG49_04980) | - | 1043154..1044200 (-) | 1047 | WP_245051831.1 | DNA cytosine methyltransferase | - |
| MPG49_RS04985 (MPG49_04985) | - | 1044292..1044915 (-) | 624 | WP_245051832.1 | GIY-YIG nuclease family protein | - |
| MPG49_RS04990 (MPG49_04990) | - | 1044975..1045847 (-) | 873 | WP_245051833.1 | DNA adenine methylase | - |
| MPG49_RS04995 (MPG49_04995) | typA | 1045863..1047662 (-) | 1800 | WP_000790233.1 | translational GTPase TypA | - |
| MPG49_RS05000 (MPG49_05000) | - | 1047708..1048556 (-) | 849 | WP_245051834.1 | glycosyltransferase family 9 protein | - |
| MPG49_RS05005 (MPG49_05005) | - | 1048522..1050158 (-) | 1637 | Protein_969 | class I SAM-dependent methyltransferase | - |
| MPG49_RS05010 (MPG49_05010) | hopJ | 1050167..1051267 (-) | 1101 | WP_245051835.1 | Hop family outer membrane protein HopJ/HopK | - |
| MPG49_RS05015 (MPG49_05015) | gltX | 1051385..1052776 (+) | 1392 | WP_245051836.1 | glutamate--tRNA ligase | - |
| MPG49_RS05020 (MPG49_05020) | - | 1052874..1053656 (-) | 783 | WP_245051837.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 594 a.a. Molecular weight: 68818.14 Da Isoelectric Point: 9.7467
>NTDB_id=667994 MPG49_RS04670 WP_245051790.1 978103..979887(+) (uvrC) [Helicobacter pylori strain Hpfe0001]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQFKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKVLKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHKYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQFKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKVLKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHKYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
Nucleotide
Download Length: 1785 bp
>NTDB_id=667994 MPG49_RS04670 WP_245051790.1 978103..979887(+) (uvrC) [Helicobacter pylori strain Hpfe0001]
ATGGCTGATTTATTGTCTAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGTTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAACAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGTTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAGTTTTAAAACAGCCTGGTGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCCATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAAATCTTACTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCATAAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCACGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGTAGCGGGAGT
TTTGTAGAAGTAATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTACTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAAGGCATA
GGAGAAGCTAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA
ATGGCTGATTTATTGTCTAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGTTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAACAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGTTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAGTTTTAAAACAGCCTGGTGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCCATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAAATCTTACTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCATAAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCACGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGTAGCGGGAGT
TTTGTAGAAGTAATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTACTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAAGGCATA
GGAGAAGCTAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| uvrC | Helicobacter pylori 26695 |
96.801 |
100 |
0.968 |