Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG81_RS03130 Genome accession   NZ_CP094151
Coordinates   651545..653329 (-) Length   594 a.a.
NCBI ID   WP_245088031.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe019     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 646545..658329
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG81_RS03100 (MPG81_03100) - 647141..647389 (+) 249 WP_000790557.1 RNA-binding protein -
  MPG81_RS03105 (MPG81_03105) - 647587..648408 (-) 822 WP_245088027.1 glycosyltransferase family 25 protein -
  MPG81_RS03110 (MPG81_03110) trxB 648574..649509 (-) 936 WP_024773194.1 thioredoxin-disulfide reductase -
  MPG81_RS03115 (MPG81_03115) trxA 649515..649835 (-) 321 WP_000020200.1 thioredoxin -
  MPG81_RS03120 (MPG81_03120) - 649924..650268 (-) 345 WP_001211660.1 YraN family protein -
  MPG81_RS03125 (MPG81_03125) - 650269..651534 (-) 1266 WP_245088029.1 homoserine dehydrogenase -
  MPG81_RS03130 (MPG81_03130) uvrC 651545..653329 (-) 1785 WP_245088031.1 excinuclease ABC subunit UvrC Machinery gene
  MPG81_RS03135 (MPG81_03135) - 653330..653791 (-) 462 WP_245088033.1 hypothetical protein -
  MPG81_RS03140 (MPG81_03140) - 653783..653962 (+) 180 WP_000468796.1 hypothetical protein -
  MPG81_RS03145 (MPG81_03145) - 653974..654615 (-) 642 WP_245088035.1 ABC transporter ATP-binding protein -
  MPG81_RS03150 (MPG81_03150) - 654619..656280 (-) 1662 WP_245088038.1 ABC transporter permease/substrate-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68682.93 Da        Isoelectric Point: 9.6257

>NTDB_id=667685 MPG81_RS03130 WP_245088031.1 651545..653329(-) (uvrC) [Helicobacter pylori strain Hpfe019]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFQLECMPYRVEIFDV
SHHANSQCVGGMVVYENHAFQKDSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667685 MPG81_RS03130 WP_245088031.1 651545..653329(-) (uvrC) [Helicobacter pylori strain Hpfe019]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGACAAAAACCGCCAATT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTAGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAACCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTCCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAAGCGGT
GTTAGTGAAAATGTTTATGCGTGGAGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCCCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTCAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCTAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGCATTCCAAAAAGACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGAGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTACTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCCATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971

Multiple sequence alignment