Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPF84_RS04670 Genome accession   NZ_CP094149
Coordinates   982164..983948 (+) Length   594 a.a.
NCBI ID   WP_245084915.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe023     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 977164..988948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPF84_RS04635 (MPF84_04635) - 977196..977540 (+) 345 Protein_903 osmoprotection protein -
  MPF84_RS04640 (MPF84_04640) - 977557..978129 (-) 573 WP_000916526.1 Hpy99I family type II restriction endonuclease -
  MPF84_RS04645 (MPF84_04645) - 978123..978941 (-) 819 WP_039704601.1 site-specific DNA-methyltransferase -
  MPF84_RS04650 (MPF84_04650) - 979317..980873 (+) 1557 WP_245084907.1 ABC transporter permease/substrate-binding protein -
  MPF84_RS04655 (MPF84_04655) - 980878..981519 (+) 642 WP_245084909.1 ATP-binding cassette domain-containing protein -
  MPF84_RS04660 (MPF84_04660) - 981531..981710 (-) 180 WP_000468796.1 hypothetical protein -
  MPF84_RS04665 (MPF84_04665) - 981702..982163 (+) 462 WP_245084912.1 hypothetical protein -
  MPF84_RS04670 (MPF84_04670) uvrC 982164..983948 (+) 1785 WP_245084915.1 excinuclease ABC subunit UvrC Machinery gene
  MPF84_RS04675 (MPF84_04675) - 983959..985224 (+) 1266 WP_000746802.1 homoserine dehydrogenase -
  MPF84_RS04680 (MPF84_04680) - 985225..985569 (+) 345 WP_057112448.1 YraN family protein -
  MPF84_RS04685 (MPF84_04685) trxA 985658..985978 (+) 321 WP_000020200.1 thioredoxin -
  MPF84_RS04690 (MPF84_04690) trxB 985984..986919 (+) 936 WP_245056506.1 thioredoxin-disulfide reductase -
  MPF84_RS04695 (MPF84_04695) - 987087..987959 (+) 873 WP_245084919.1 glycosyltransferase family 25 protein -
  MPF84_RS04700 (MPF84_04700) - 988107..988355 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68906.12 Da        Isoelectric Point: 9.7128

>NTDB_id=667642 MPF84_RS04670 WP_245084915.1 982164..983948(+) (uvrC) [Helicobacter pylori strain Hpfe023]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIRSYFSIRNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGTKDIIHTASDTFKLLPSDKRLQWVQKLRDESHRYVINFHRSTKLKNMKQITLLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667642 MPF84_RS04670 WP_245084915.1 982164..983948(+) (uvrC) [Helicobacter pylori strain Hpfe023]
ATGGCTGATTTGTTGTCTAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAGAAGCTATTTTTCTATCCGTAATAATGAAATCACGCCCA
ATCATCGCACCAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTGAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACTAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCCATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCCTTAATGCCTGAACAAATCTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCTAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCACTAAAGACATTAT
CCATACCGCTAGCGATACTTTTAAATTACTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGTGATGAAAGCC
ACCGGTATGTGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCACTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
TGCCGTTTTAAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.627

99.832

0.965

Multiple sequence alignment