Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG02_RS04485 Genome accession   NZ_CP094142
Coordinates   946939..948723 (+) Length   594 a.a.
NCBI ID   WP_245075013.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe033     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 941939..953723
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG02_RS04450 (MPG02_04450) - 941986..942231 (+) 246 Protein_868 osmoprotection protein -
  MPG02_RS04455 (MPG02_04455) - 942243..942815 (-) 573 WP_021300186.1 Hpy99I family type II restriction endonuclease -
  MPG02_RS04460 (MPG02_04460) - 942809..943627 (-) 819 WP_154421775.1 site-specific DNA-methyltransferase -
  MPG02_RS04465 (MPG02_04465) - 943988..945649 (+) 1662 WP_245075011.1 ABC transporter permease/substrate-binding protein -
  MPG02_RS04470 (MPG02_04470) - 945653..946294 (+) 642 WP_245075012.1 ABC transporter ATP-binding protein -
  MPG02_RS04475 (MPG02_04475) - 946306..946485 (-) 180 WP_000468796.1 hypothetical protein -
  MPG02_RS04480 (MPG02_04480) - 946477..946938 (+) 462 WP_000437188.1 hypothetical protein -
  MPG02_RS04485 (MPG02_04485) uvrC 946939..948723 (+) 1785 WP_245075013.1 excinuclease ABC subunit UvrC Machinery gene
  MPG02_RS04490 (MPG02_04490) - 948734..949999 (+) 1266 WP_245075014.1 homoserine dehydrogenase -
  MPG02_RS04495 (MPG02_04495) - 950000..950344 (+) 345 WP_001211660.1 YraN family protein -
  MPG02_RS04500 (MPG02_04500) trxA 950433..950753 (+) 321 WP_000020200.1 thioredoxin -
  MPG02_RS04505 (MPG02_04505) trxB 950759..951694 (+) 936 WP_245075015.1 thioredoxin-disulfide reductase -
  MPG02_RS04510 (MPG02_04510) - 951862..952683 (+) 822 WP_245075016.1 glycosyltransferase family 25 protein -
  MPG02_RS04515 (MPG02_04515) - 952883..953131 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68771.99 Da        Isoelectric Point: 9.7128

>NTDB_id=667515 MPG02_RS04485 WP_245075013.1 946939..948723(+) (uvrC) [Helicobacter pylori strain Hpfe033]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIRSYFSIRNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGGNKAVLVKMFMRGGKIISSAFEKIHSHNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLARRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTASDTFKLIPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667515 MPG02_RS04485 WP_245075013.1 946939..948723(+) (uvrC) [Helicobacter pylori strain Hpfe033]
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAGAAGCTATTTTTCTATCCGTAATAATGAAATCACGCCCA
ATCATCGCACAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTGAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAACCTGGCGTTA
AATATTTTGGTCCTTTTACAAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAGCTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGGGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCATTCTCATAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATCTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCGCCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGGGGGAGAGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGTGCTAAAGACATTAT
CCACACCGCTAGCGATACTTTTAAATTGATCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.801

100

0.968

Multiple sequence alignment