Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG35_RS04425 Genome accession   NZ_CP094138
Coordinates   941272..943056 (+) Length   594 a.a.
NCBI ID   WP_245019242.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe037     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 936272..948056
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG35_RS04390 (MPG35_04390) - 936312..936565 (+) 254 Protein_851 osmoprotection protein -
  MPG35_RS04395 (MPG35_04395) - 936577..937149 (-) 573 WP_245019238.1 Hpy99I family type II restriction endonuclease -
  MPG35_RS04400 (MPG35_04400) - 937143..937961 (-) 819 WP_089482685.1 site-specific DNA-methyltransferase -
  MPG35_RS04405 (MPG35_04405) - 938321..939982 (+) 1662 WP_245019239.1 ABC transporter permease/substrate-binding protein -
  MPG35_RS04410 (MPG35_04410) - 939986..940627 (+) 642 WP_245019240.1 ABC transporter ATP-binding protein -
  MPG35_RS04415 (MPG35_04415) - 940639..940818 (-) 180 WP_000468796.1 hypothetical protein -
  MPG35_RS04420 (MPG35_04420) - 940810..941271 (+) 462 WP_245019241.1 hypothetical protein -
  MPG35_RS04425 (MPG35_04425) uvrC 941272..943056 (+) 1785 WP_245019242.1 excinuclease ABC subunit UvrC Machinery gene
  MPG35_RS04430 (MPG35_04430) - 943067..944332 (+) 1266 WP_245019243.1 homoserine dehydrogenase -
  MPG35_RS04435 (MPG35_04435) - 944333..944677 (+) 345 WP_154443339.1 YraN family protein -
  MPG35_RS04440 (MPG35_04440) trxA 944766..945086 (+) 321 WP_000020200.1 thioredoxin -
  MPG35_RS04445 (MPG35_04445) trxB 945092..946027 (+) 936 WP_245019244.1 thioredoxin-disulfide reductase -
  MPG35_RS04450 (MPG35_04450) - 946194..947015 (+) 822 WP_245019245.1 glycosyltransferase family 25 protein -
  MPG35_RS04455 (MPG35_04455) - 947219..947467 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68705.90 Da        Isoelectric Point: 9.7098

>NTDB_id=667453 MPG35_RS04425 WP_245019242.1 941272..943056(+) (uvrC) [Helicobacter pylori strain Hpfe037]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECTPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTASDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667453 MPG35_RS04425 WP_245019242.1 941272..943056(+) (uvrC) [Helicobacter pylori strain Hpfe037]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGTTATTTTTCTGTCCGCAATAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGAATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGCAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAACAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATCTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCACGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGTCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATCAT
CCACACCGCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTTCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971

Multiple sequence alignment