Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG73_RS04745 Genome accession   NZ_CP094122
Coordinates   997743..999527 (+) Length   594 a.a.
NCBI ID   WP_245056585.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe058     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 992743..1004527
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG73_RS04715 (MPG73_04715) motB 993406..994173 (+) 768 WP_001085319.1 flagellar motor protein MotB -
  MPG73_RS04720 (MPG73_04720) - 994177..994614 (+) 438 WP_220860406.1 hypothetical protein -
  MPG73_RS04725 (MPG73_04725) - 994794..996455 (+) 1662 WP_245056579.1 ABC transporter permease/substrate-binding protein -
  MPG73_RS04730 (MPG73_04730) - 996457..997098 (+) 642 WP_245056581.1 ATP-binding cassette domain-containing protein -
  MPG73_RS04735 (MPG73_04735) - 997110..997289 (-) 180 WP_000468796.1 hypothetical protein -
  MPG73_RS04740 (MPG73_04740) - 997281..997742 (+) 462 WP_245056583.1 hypothetical protein -
  MPG73_RS04745 (MPG73_04745) uvrC 997743..999527 (+) 1785 WP_245056585.1 excinuclease ABC subunit UvrC Machinery gene
  MPG73_RS04750 (MPG73_04750) - 999538..1000803 (+) 1266 WP_245056586.1 homoserine dehydrogenase -
  MPG73_RS04755 (MPG73_04755) - 1000804..1001148 (+) 345 WP_001211660.1 YraN family protein -
  MPG73_RS04760 (MPG73_04760) trxA 1001237..1001557 (+) 321 WP_000020200.1 thioredoxin -
  MPG73_RS04765 (MPG73_04765) trxB 1001563..1002498 (+) 936 WP_245056588.1 thioredoxin-disulfide reductase -
  MPG73_RS04770 (MPG73_04770) - 1002665..1003486 (+) 822 WP_245056590.1 glycosyltransferase family 25 protein -
  MPG73_RS04775 (MPG73_04775) - 1003691..1003939 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68782.07 Da        Isoelectric Point: 9.5679

>NTDB_id=667176 MPG73_RS04745 WP_245056585.1 997743..999527(+) (uvrC) [Helicobacter pylori strain Hpfe058]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNYRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMECLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667176 MPG73_RS04745 WP_245056585.1 997743..999527(+) (uvrC) [Helicobacter pylori strain Hpfe058]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCAAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCACAATAATGAAATCACGCCCA
ATTATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAACAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGTGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGTGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCCATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTCGCCAAAGAAC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGTGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGAGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.801

100

0.968

Multiple sequence alignment