Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG78_RS03650 Genome accession   NZ_CP094119
Coordinates   739941..741725 (-) Length   594 a.a.
NCBI ID   WP_245041004.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe064     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 734941..746725
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG78_RS03620 (MPG78_03620) - 735528..735776 (+) 249 WP_000790557.1 RNA-binding protein -
  MPG78_RS03625 (MPG78_03625) - 735981..736802 (-) 822 WP_024773193.1 glycosyltransferase family 25 protein -
  MPG78_RS03630 (MPG78_03630) trxB 736970..737905 (-) 936 WP_140581696.1 thioredoxin-disulfide reductase -
  MPG78_RS03635 (MPG78_03635) trxA 737911..738231 (-) 321 WP_000020200.1 thioredoxin -
  MPG78_RS03640 (MPG78_03640) - 738320..738664 (-) 345 WP_180450246.1 YraN family protein -
  MPG78_RS03645 (MPG78_03645) - 738665..739930 (-) 1266 WP_245041002.1 homoserine dehydrogenase -
  MPG78_RS03650 (MPG78_03650) uvrC 739941..741725 (-) 1785 WP_245041004.1 excinuclease ABC subunit UvrC Machinery gene
  MPG78_RS03655 (MPG78_03655) - 741726..742187 (-) 462 WP_245041006.1 hypothetical protein -
  MPG78_RS03660 (MPG78_03660) - 742179..742358 (+) 180 WP_000468796.1 hypothetical protein -
  MPG78_RS03665 (MPG78_03665) - 742370..743011 (-) 642 WP_245041007.1 ATP-binding cassette domain-containing protein -
  MPG78_RS03670 (MPG78_03670) - 743013..744674 (-) 1662 WP_245041009.1 ABC transporter permease/substrate-binding protein -
  MPG78_RS03675 (MPG78_03675) - 744854..745291 (-) 438 WP_001031792.1 hypothetical protein -
  MPG78_RS03680 (MPG78_03680) motB 745295..746062 (-) 768 WP_001085319.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68766.04 Da        Isoelectric Point: 9.7128

>NTDB_id=667115 MPG78_RS03650 WP_245041004.1 739941..741725(-) (uvrC) [Helicobacter pylori strain Hpfe064]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSTFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKDSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKMLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667115 MPG78_RS03650 WP_245041004.1 739941..741725(-) (uvrC) [Helicobacter pylori strain Hpfe064]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGTTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGTGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCCTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAACATTTGAAAAAATCCACTCTCTCAACGGATTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCCCACCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGTGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGCATTCCAAAAAGACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGTGCTAAAGACATCAT
CCACACCGCTAACGATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAAGGCATA
GGAGAAGCCAGCGTGAAAAAAATGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.475

100

0.975

Multiple sequence alignment